| Long-term cigarette smoking is associated with increased myocardial perfusion heterogeneity assessed by positron emission tomography. | |
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MedLine Citation:
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PMID: 8854839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathophysiology of smoking-related coronary events in patients with normal coronary arteries is incompletely understood. This study was conducted to explore, in subjects without symptoms of cardiovascular disease, the long-term effects of smoking on regional coronary artery vasoactivity, especially during sympathetic stimulation. In ten smoking and ten non-smoking sex- and age-matched healthy volunteers, segmental myocardial perfusion was studied using dynamic parametric nitrogen-13 ammonia positron emission tomography at rest and during sympathetic stimulation evoked by the cold pressor stimulation. Smokers demonstrated a higher myocardial perfusion at rest (116+/-17 ml/min/100 g vs 96+/-20 ml/min/100 g, P <0.01) and an impaired myocardial perfusion increase during cold pressor stimulation (1.02+/-0.15 vs 1.18+/-0.17, P <0.05). The heterogeneity of perfusion, expressed as coefficient of variation, was significantly different between the smoking and the non-smoking group. The coefficient of variation of segmental myocardial perfusion was higher in smokers at rest (17.5%+/-4.2% vs 13.5%+/-1. 9%, P <0.05) and during cold pressor stimulation (17.0%+/-3.2% vs 13. 9%+/-1.8%, P <0.05). We conclude that the long-term effects of smoking in healthy volunteers are associated with (1) increased myocardial perfusion at rest, (2) impaired myocardial perfusion response to cold pressor stimulation, and (3) increased myocardial perfusion heterogeneity both at rest and during cold pressor stimulation. These results may suggest that in healthy subjects the long-term effect of smoking is related to abnormal coronary artery vasoactivity, presumably induced by an interplay of regional endothelial dysfunction and autonomic dysregulation. |
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Authors:
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J G Meeder; P K Blanksma; E E van der Wall; R L Anthonio; A T Willemsen; J Pruim; W Vaalburg; K I Lie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 23 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-06 Completed Date: 1997-03-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1442-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology and National Research PET Center, University Hospital Groningen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autonomic Nervous System / physiology Case-Control Studies Cold Temperature / diagnostic use Coronary Circulation / physiology Coronary Vessels / physiopathology* Endothelium, Vascular / physiology Female Heart / radionuclide imaging* Humans Male Nitrogen Radioisotopes / diagnostic use Pressoreceptors / physiology Smoking / physiopathology* Time Factors Tomography, Emission-Computed* |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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