| Long-term central infusion of adiponectin improves energy and glucose homeostasis by decreasing fat storage and suppressing hepatic gluconeogenesis without changing food intake. | |
| | |
MedLine Citation:
|
PMID: 21599766 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Adiponectin is known to be an anti-diabetic adipocytokine. However, the action mechanism by which it produces this effect remains controversial. Here, we investigated the long-term central effect of adiponectin on energy homeostasis, peripheral insulin resistance, β-cell function and mass in rats and sought to determine the mechanism by which its effect was achieved. Intracerebroventricular (ICV) infusion of adiponectin (50 ng/hour) and artificial cerebrospinal fluid (CSF) was conducted by means of an osmotic pump for 4 weeks on non-diabetic rats and 90% pancreatectomized diabetic rats that were both fed 45% energy fat diets. After 4-weeks of treatment, ICV adiponectin improved hypothalamic insulin/leptin signaling in non-diabetic and diabetic rats in comparison to ICV CSF but it did not change the phosphorylation of AMP kinase (AMPK) in the hypothalamus. Adiponectin infusion decreased epididymal fats, representing visceral fat, by increasing energy expenditure and fat oxidation. During euglycemic hyperinsulinemic clamp, ICV adiponectin improved whole body insulin sensitivity and decreased hepatic glucose output in a hyperinsulinemic clamped state by attenuating hepatic insulin resistance. Central infusion of adiponectin did not modulate glucose-stimulated insulin secretion at hyperglycemic clamp in comparison to ICV CSF infusion but it enhanced insulin sensitivity at a hyperglycemic state. Although there were no changes in insulin secretion capacity, central adiponectin increased pancreatic β-cell mass in non-diabetic and diabetic rats as a result of decreasing β-cell death. In conclusion, long-term central infusion of adiponectin enhanced energy homeostasis by increasing energy expenditure via activating hypothalamic leptin and insulin signaling pathways but without potentiating AMPK signaling; it also improved glucose homeostasis by attenuating insulin resistance. |
| | |
Authors:
|
Sunmin Park; Da Sol Kim; Dae Young Kwon; Hye Jeong Yang |
Related Documents
:
|
2060426 - Von willebrand factor and endothelial abnormalities in diabetic microangiopathy. 19531576 - Qtl for several metabolic traits map to loci controlling growth and body composition in... 10601096 - Preimplantation access to maternal insulin and albumin increases fetal growth rate in m... 2256946 - Effects of exogenous growth hormone on insulin action and glucose metabolism in the dwa... 15544426 - Adiponectin, an adipocyte-derived protein. 3527516 - The metabolic response to insulin deprivation in idiopathic brittle diabetes. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-20 |
Journal Detail:
|
Title: Journal of neuroendocrinology Volume: - ISSN: 1365-2826 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Journal of Neuroendocrinology © 2011 Blackwell Publishing. |
Affiliation:
|
Dept. of Food & Nutrition, College of Natural Science, Obesity/Diabetes Research Institutes, Hoseo University, Asan-Si, Korea Food Functional Research Division, Korean Food Research Institutes, Sungnam-Si, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative Study on 15-Ketodihydro-PGF(2?) Plasma Concentrations in Newborn Horses, Donkeys and Cal...
Next Document: Oral vitamin A as an adjunct treatment for canine sebaceous adenitis.