Document Detail

Long-term central hemodynamic effects at rest and during exercise of losartan in essential hypertension.
MedLine Citation:
PMID:  11011337     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Losartan reduces blood pressure in patients with essential hypertension, but the long-term central hemodynamic effects at rest and during exercise are not known. METHODS AND RESULTS: After 8 months of losartan treatment (50 to 100 mg daily, mean 82 mg), intra-arterial pressure was reduced from 165/102 mm Hg to 145/91 mm Hg at rest and from 193/104 mm Hg to 179/96 mm Hg during 100 W exercise in 28 patients with essential hypertension. Cardiac index and heart rate remained unchanged, but total peripheral resistance index was reduced 12% to 15%. Stroke index was unchanged at rest but increased 7% to 9% during exercise. Twenty-four-hour ambulatory blood pressure was reduced 10% to 13%. Left ventricular mass was reduced 27% in patients with left ventricular hypertrophy (n = 18). CONCLUSION: Losartan lowers blood pressure by reducing total peripheral resistance at rest and during exercise but cardiac pump function is unchanged or slightly improved. In patients with left ventricular hypertrophy, losartan induces a sizeable reduction in left ventricular mass.
P Omvik; E Gerdts; O L Myking; P Lund-Johansen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  140     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-11-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-30     Citation Subset:  AIM; IM    
Institute of Internal Medicine, Department of Cardiology, Bergen, Norway.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology
Echocardiography, Doppler, Color
Exercise / physiology*
Follow-Up Studies
Heart Ventricles / ultrasonography
Hemodynamics / drug effects,  physiology*
Hypertension / drug therapy,  physiopathology*,  ultrasonography
Hypertrophy, Left Ventricular / physiopathology,  prevention & control,  ultrasonography
Losartan / therapeutic use*
Middle Aged
Rest / physiology*
Reg. No./Substance:
0/Antihypertensive Agents; 114798-26-4/Losartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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