| Long-term central hemodynamic effects at rest and during exercise of losartan in essential hypertension. | |
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MedLine Citation:
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PMID: 11011337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Losartan reduces blood pressure in patients with essential hypertension, but the long-term central hemodynamic effects at rest and during exercise are not known. METHODS AND RESULTS: After 8 months of losartan treatment (50 to 100 mg daily, mean 82 mg), intra-arterial pressure was reduced from 165/102 mm Hg to 145/91 mm Hg at rest and from 193/104 mm Hg to 179/96 mm Hg during 100 W exercise in 28 patients with essential hypertension. Cardiac index and heart rate remained unchanged, but total peripheral resistance index was reduced 12% to 15%. Stroke index was unchanged at rest but increased 7% to 9% during exercise. Twenty-four-hour ambulatory blood pressure was reduced 10% to 13%. Left ventricular mass was reduced 27% in patients with left ventricular hypertrophy (n = 18). CONCLUSION: Losartan lowers blood pressure by reducing total peripheral resistance at rest and during exercise but cardiac pump function is unchanged or slightly improved. In patients with left ventricular hypertrophy, losartan induces a sizeable reduction in left ventricular mass. |
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Authors:
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P Omvik; E Gerdts; O L Myking; P Lund-Johansen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 140 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-10-18 Completed Date: 2000-11-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 624-30 Citation Subset: AIM; IM |
Affiliation:
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Institute of Internal Medicine, Department of Cardiology, Bergen, Norway. Per.Omvik@meda.uib.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / therapeutic use* Blood Pressure Monitoring, Ambulatory Circadian Rhythm / physiology Echocardiography, Doppler, Color Exercise / physiology* Female Follow-Up Studies Heart Ventricles / ultrasonography Hemodynamics / drug effects, physiology* Humans Hypertension / drug therapy, physiopathology*, ultrasonography Hypertrophy, Left Ventricular / physiopathology, prevention & control, ultrasonography Losartan / therapeutic use* Male Middle Aged Prognosis Rest / physiology* Safety |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 114798-26-4/Losartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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