Document Detail

Long-term cardiac sequelae of Kawasaki disease.
MedLine Citation:
PMID:  11123078     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease is the leading cause of acquired heart disease in childhood. Despite treatment with intravenous gamma globulin, 2% to 4% of patients have coronary abnormalities. Those with giant aneurysms are at risk for stenosis and myocardial ischemia/infarction, and require aggressive anticoagulation with frequent follow-up, including stress testing and coronary angiography. In rare cases, patients will have coronary artery bypass grafting. Those with less severe coronary involvement need antiplatelet therapy and infrequent noninvasive testing. Patients with normal echos after the acute phase are not treated, but the future impact of the disease is not certain particularly in the setting of adult onset coronary artery disease.
D R Fulton; J W Newburger
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  2     ISSN:  1523-3774     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2002-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  324-9     Citation Subset:  IM    
Department of Cardiology, Children's Hospital of Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Aspirin / administration & dosage,  therapeutic use
Child, Preschool
Coronary Aneurysm / diagnosis,  etiology
Coronary Angiography
Coronary Disease / etiology,  radiography
Follow-Up Studies
Heart Catheterization
Heart Diseases / diagnosis,  drug therapy,  etiology*
Immunoglobulins, Intravenous / therapeutic use
Mucocutaneous Lymph Node Syndrome / complications*,  diagnosis
Myocardial Infarction / drug therapy,  etiology
Platelet Aggregation Inhibitors / administration & dosage,  therapeutic use
Thrombolytic Therapy
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Immunoglobulins, Intravenous; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin

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