Document Detail

Long-term caffeine inhibits Ehrlich ascites carcinoma cell-induced induction of central GABAergic activity.
MedLine Citation:
PMID:  11071364     Owner:  NLM     Status:  MEDLINE    
Long-term administration (for 22-27 consecutive days) of caffeine (20 mg/kg/day p.o) developed tolerance to this drug by upregulating the central GABAergic activity. Development of Ehrlich ascites carcinoma (EAC) cell induced the whole brain GABAergic activity. But pretreatment of caffeine and continuation of its treatment in the course of development of EAC cells restored the EAC cell-induced change of GABAergic activity to control values. Thus, it may be concluded that caffeine (adenosine receptor antagonist) suppresses the EAC cell-induced induction of whole brain GABAergic activity in mice.
S Mukhopadhyay; M K Poddar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurochemical research     Volume:  25     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-02-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1457-63     Citation Subset:  IM    
Department of Biochemistry, University of Calcutta, India.
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MeSH Terms
Caffeine / pharmacology*
Carcinoma, Ehrlich Tumor / metabolism*,  pathology
GABA Antagonists / pharmacology*
Neoplasm Transplantation
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
0/GABA Antagonists; 56-12-2/gamma-Aminobutyric Acid; 58-08-2/Caffeine

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