| Long-term caffeine inhibits Ehrlich ascites carcinoma cell-induced induction of central GABAergic activity. | |
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MedLine Citation:
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PMID: 11071364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-term administration (for 22-27 consecutive days) of caffeine (20 mg/kg/day p.o) developed tolerance to this drug by upregulating the central GABAergic activity. Development of Ehrlich ascites carcinoma (EAC) cell induced the whole brain GABAergic activity. But pretreatment of caffeine and continuation of its treatment in the course of development of EAC cells restored the EAC cell-induced change of GABAergic activity to control values. Thus, it may be concluded that caffeine (adenosine receptor antagonist) suppresses the EAC cell-induced induction of whole brain GABAergic activity in mice. |
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Authors:
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S Mukhopadhyay; M K Poddar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurochemical research Volume: 25 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-02-05 Completed Date: 2001-02-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1457-63 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Calcutta, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caffeine / pharmacology* Carcinoma, Ehrlich Tumor / metabolism*, pathology Female GABA Antagonists / pharmacology* Mice Neoplasm Transplantation gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/GABA Antagonists; 56-12-2/gamma-Aminobutyric Acid; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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