Document Detail


Long-term cadaver allograft survival in the recipient with a positive B lymphocyte crossmatch.
MedLine Citation:
PMID:  373188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over a 2 1/2-year period, prospective standard, T, and B lymphocyte crossmatches were performed in 45 cadaver renal transplants using the microlymphocytotoxicity technique. Twenty-three of the 45 recipients had a positive B lymphocyte crossmatch. Cumulative graft survival rates did not differ between recipients with a positive and negative B lymphocyte crossmatch. High levels of presensitization in routine lymphocytotoxic antibody screening or transplant number did not adversely affect graft survival in recipients with a positive B lymphocyte crossmatch. Five recipients had moderately positive standard crossmatches which were attributable to anti-B lymphocytotoxicity. Four of these five grafts are presently functioning with normal serum creatinine levels 9 to 14 months post-transplant. A positive B lymphocyte crossmatch is compatible with good long-term cadaveric renal allograft survival. In addition, a weakly positive standard crossmatch is not a contraindication to transplantation when the positive crossmatch is attributable to anti-B lymphocyte antibody.
Authors:
R B Ettenger; C H Uittenbogaart; A J Pennisi; M H Malekzadeh; R N Fine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  27     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-06-26     Completed Date:  1979-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies
B-Lymphocytes / immunology*
Child
Child, Preschool
Graft Survival*
Humans
Kidney Transplantation
Transplantation, Homologous*
Chemical
Reg. No./Substance:
0/Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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