| Long-term cadaver allograft survival in the recipient with a positive B lymphocyte crossmatch. | |
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MedLine Citation:
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PMID: 373188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over a 2 1/2-year period, prospective standard, T, and B lymphocyte crossmatches were performed in 45 cadaver renal transplants using the microlymphocytotoxicity technique. Twenty-three of the 45 recipients had a positive B lymphocyte crossmatch. Cumulative graft survival rates did not differ between recipients with a positive and negative B lymphocyte crossmatch. High levels of presensitization in routine lymphocytotoxic antibody screening or transplant number did not adversely affect graft survival in recipients with a positive B lymphocyte crossmatch. Five recipients had moderately positive standard crossmatches which were attributable to anti-B lymphocytotoxicity. Four of these five grafts are presently functioning with normal serum creatinine levels 9 to 14 months post-transplant. A positive B lymphocyte crossmatch is compatible with good long-term cadaveric renal allograft survival. In addition, a weakly positive standard crossmatch is not a contraindication to transplantation when the positive crossmatch is attributable to anti-B lymphocyte antibody. |
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Authors:
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R B Ettenger; C H Uittenbogaart; A J Pennisi; M H Malekzadeh; R N Fine |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation Volume: 27 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1979 May |
Date Detail:
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Created Date: 1979-06-26 Completed Date: 1979-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 315-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies B-Lymphocytes / immunology* Child Child, Preschool Graft Survival* Humans Kidney Transplantation Transplantation, Homologous* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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