Document Detail


Long-term cabergoline therapy is not associated with valvular heart disease in patients with prolactinomas.
MedLine Citation:
PMID:  18594989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ergot-derived dopamine receptor agonists, especially pergolide and cabergoline, have been associated with an increased risk of valvular heart disease in patients treated for Parkinson's disease. Cabergoline at lower doses than those employed in Parkinson's disease is widely used in patients with prolactinomas, because of its high efficacy and tolerability; however, its safety with regard to cardiac valve disease is unknown. In order to assess the prevalence of cardiac valve regurgitation in patients with prolactinomas treated with long-term cabergoline, we performed a prospective and multicentric study including four university centers in the province of Quebec. A transthoracic echocardiogram was performed in 70 patients with prolactinomas treated with cabergoline for at least 1 year (duration of treatment, 55 +/- 22 months; cumulative dose 282 +/- 271 mg, mean +/- SD) and 70 control subjects matched for age and sex. Valvular regurgitation was graded according to the American Society of Echocardiography recommendations as mild, moderate, or severe. Moderate valvular regurgitation was found in four patients (5.7%) and five control subjects (7.1%) (P = 0.73). No patient had severe valvular regurgitation. There was no correlation between the presence of significant heart-valve regurgitation and cabergoline cumulative dose, duration of cabergoline treatment, prior use of bromocriptine, age, adenoma size, or prolactin levels. Our results show that low doses of cabergoline seem to be a safe treatment of hyperprolactinemic patients. However, in patients with prolonged cabergoline treatment, we suggest that echocardiographic surveillance may be warranted.
Authors:
Sophie Vallette; Karim Serri; Juan Rivera; Patricia Santagata; Sophie Delorme; Natasha Garfield; Nora Kahtani; Hugues Beauregard; Nahla Aris-Jilwan; Ghislaine Houde; Omar Serri
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Pituitary     Volume:  12     ISSN:  1573-7403     ISO Abbreviation:  Pituitary     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-10-20     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9814578     Medline TA:  Pituitary     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Hôpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, 1560 Sherbrooke East, Montreal, QC, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Dopamine Agonists / adverse effects,  therapeutic use*
Echocardiography
Ergolines / adverse effects,  therapeutic use*
Female
Heart Valve Diseases / complications*
Humans
Male
Middle Aged
Prolactinoma / complications*,  drug therapy*
Chemical
Reg. No./Substance:
0/Dopamine Agonists; 0/Ergolines; LL60K9J05T/cabergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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