| Long-term beta blockers for stable angina: systematic review and meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 22779086 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVES: To assess the effects of long-term beta blockers in patients with stable angina. METHODS: We reviewed the literature up to June 2010 from CENTRAL, MEDLINE, EMBASE, CBM, and CNKI for randomized controlled trials. The appropriate data were meta-analysed using Revman 5.0. RESULTS: Twenty-six trials including 6108 patients were identified. The treatment with beta blockers has significantly decreased all-cause mortality when compared with no control (OR 0.40, 95% CI 0.20 to 0.79), but has had no statistically differences when compared with placebo (OR 0.92, 95% CI 0.62 to 1.38) and with calcium-channel blocker (CCB) (OR0.84, 95% CI 0.49 to 1.44). This was similar in patients with fatal and non-fatal acute myocardial infarction when compared with placebo (OR 0.82, 95% CI 0.57 to 1.17) or CCB (OR 1.08, 95% CI 0.71 to 1.66); on revascularization and quality of life. The beta blockers reduced the incident of unstable angina compared to no treatment (OR 0.14, 95% CI0.07 to 0.29), but increased unstable angina compared to placebo (OR 3.32, 95% CI 1.50 to 7.36). There was a significant reduction of nitrate consumption when beta blockers were compared with CCBs (OR 1.18, 95% CI 1.54 to 0.82),but not with placebo and trimetazidine. There was no significant difference in angina attack between each group. Side effects in beta blocker were similar with ones in controls. CONCLUSIONS: Beta blockers may decrease the death and unstable angina when compared with no treatment, but no more effective than other anti-anginal agents on prophylaxis of myocardial ischaemia in stable angina patients. |
| | |
Authors:
|
De Fen Shu; Bi Rong Dong; Xiu Fang Lin; Tai Xiang Wu; Guan Jian Liu |
Related Documents
:
|
11304106 - The consort statement: revised recommendations for improving the quality of reports of ... 22364606 - Depressive symptoms as a predictor of quality of life in cerebral small vessel disease,... 16269566 - "hello, hello--it's english i speak!": a qualitative exploration of patients' understan... 22329486 - Investigating the link between liking versus wanting self-esteem and depression in a na... 7491366 - Confirmed clinical efficacy of actovegin in elderly patients with organic brain syndrome. 1485146 - A comparison of different psychosocial questionnaires in patients with myocardial infar... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of preventive cardiology Volume: 19 ISSN: 2047-4881 ISO Abbreviation: Eur J Prev Cardiol Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-07-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101564430 Medline TA: Eur J Prev Cardiol Country: England |
Other Details:
|
Languages: eng Pagination: 330-41 Citation Subset: IM |
Affiliation:
|
Geriatrics, West China Hospital, Sichuan University, Chengdu, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nicotine, cigarette smoking and cardiac arrhythmia: an overview.
Next Document: Role of the pituitary–adrenal axis in granulocyte-colony stimulating factor-induced neuroprotectio...