Document Detail

Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study.
MedLine Citation:
PMID:  12103264     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The main objective of this study was to assess if the benefits of biventricular (BiV) pacing observed during the crossover phase were sustained over 12 months. BACKGROUND: MUltisite STimulation In Cardiomyopathies (MUSTIC) is a randomized controlled study intended to evaluate the effects of BiV pacing in patients with New York Heart Association (NYHA) class III heart failure and intraventricular conduction delay. METHODS: Of 131 patients included, 42/67 in sinus rhythm (SR) and 33/64 in atrial fibrillation (AF) were followed up longitudinally at 9 and 12 months by 6-min walked distance, peak oxygen uptake (peak VO(2)), quality of life by the Minnesota score, NYHA class, echocardiography, and left ventricular ejection fraction by radionuclide technique. RESULTS: At 12 months, all SR and 88% of AF patients were programmed to BiV pacing. Compared with baseline, the 6-min walked distance increased by 20% (SR) (p = 0.0001) and 17% (AF) (p = 0.004); the peak VO(2) by 11% (SR) and 9% (AF); quality of life improved by 36% (SR) (p = 0.0001) and 32% (AF) (p = 0.002); NYHA class improved by 25% (SR) (p = 0.0001) and 27% (AF) (p = 0.0001). The ejection fraction improved by 5% (SR) and 4% (AF). Mitral regurgitation decreased by 45% (SR) and 50% (AF). CONCLUSIONS: The clinical benefits of BiV pacing appeared to be significantly maintained over a 12-month follow-up period.
Cecilia Linde; Christophe Leclercq; Steve Rex; Stephane Garrigue; Thomas Lavergne; Serge Cazeau; William McKenna; Melissa Fitzgerald; Jean-Claude Deharo; Christine Alonso; Stuart Walker; Frieder Braunschweig; Christophe Bailleul; Jean-Claude Daubert
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  40     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-09     Completed Date:  2002-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-8     Citation Subset:  AIM; IM    
Department of Cardiology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Atrial Fibrillation / therapy
Cardiac Pacing, Artificial / methods*
Case-Control Studies
Cross-Over Studies
Exercise Tolerance
Follow-Up Studies
Heart Failure / therapy*
Hospitalization / statistics & numerical data
Middle Aged
Pacemaker, Artificial
Quality of Life
Single-Blind Method
Time Factors
Comment In:
J Am Coll Cardiol. 2003 Feb 19;41(4):709; author reply 709-10   [PMID:  12598087 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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