Document Detail

Long-term asthma outcomes after endoscopic sinus surgery in aspirin triad patients.
MedLine Citation:
PMID:  16647978     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aspirin triad disease (ATD) is a well-known clinical entity characterized by asthma, polyposis, and aspirin intolerance. Using subjective and objective clinical data, this study examines the short- and long-term outcomes of asthma after sinus surgery in patients with ATD. METHODS: A retrospective review and standardized survey in the setting of an academic tertiary rhinology program. Eighty-five patients with ATD who had endoscopic sinus surgery between 1986 and 1998 were identified from an internal database. Standardized surveys were sent to each patient to assess both objective and subjective improvement of their asthma. RESULTS: The address and location of 20 of 85 patients could not be ascertained. Thirty-four of the remaining 65 patients (52.3%) with ATD who underwent endoscopic sinus surgery responded to the survey. Respondents had a mean follow-up of 10 years. Overall, 29 (94%) of 31 patients who reported asthma symptoms preoperatively noted long-term postoperative improvement. Furthermore, 21 of these 31 patients (68%) reported further improvement of their asthma beyond the first postoperative year. Emergency department visits for asthma exacerbations decreased in 17 (94%) of 18. Inpatient hospitalizations for asthma exacerbations also decreased in the first postoperative year in 10 (91%) of 11 patients. Asthma attacks declined in 12 (41%) of 27 patients the first year, whereas 24 (88.9%) of 27 patients had fewer asthma attacks in the last 12 months of follow-up. Peak flow rates improved from an average of 60% of the predicted value preoperatively to 86% at the time of follow-up. CONCLUSIONS: The asthma component of ATD continues to improve with time after endoscopic sinus surgery. Although the most dramatic decrease occurs in the first year after sinus surgery, the majority of patients noted further improvement in subsequent years.
Todd A Loehrl; Robinson M Ferre; Robert J Toohill; Timothy L Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of otolaryngology     Volume:  27     ISSN:  0196-0709     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-10-20     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-60     Citation Subset:  IM    
Division of Rhinology and Sinus Surgery, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, 53226, USA.
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MeSH Terms
Aspirin / adverse effects*
Asthma / complications*,  prevention & control*
Chronic Disease
Drug Hypersensitivity / etiology
Endoscopy / methods*
Nasal Polyps / surgery
Peak Expiratory Flow Rate
Retrospective Studies
Rhinitis / complications*,  surgery*
Sinusitis / complications*,  surgery*
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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