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Long-term assessment of contrast effects of gadofluorine M and gadofluorine P in magnetic resonance imaging of mice.
MedLine Citation:
PMID:  22135114     Owner:  NLM     Status:  Publisher    
PURPOSE: To investigate the long-term time course of the contrast effects after the intravenous injection of gadofluorine M or gadofluorine P in mice. MATERIALS AND METHODS: Magnetic resonance images were acquired longitudinally after intravenous injection of 0.1 μmol Gd/g gadofluorine M into BALB/c mice. The contrast effects were also assessed in C57BL/6J mice injected with gadofluorine M, BALB/c mice injected with gadofluorine P, and BALB/c mice injected with a double dose of gadopentetate dimeglumine. RESULTS: The injection of gadofluorine M into BALB/c mice caused prolonged contrast effects in the blood and other organs. The liver enhancement was especially long-lasting and still evident 6 days after injection. Strain-related differences in contrast kinetics of gadofluorine M were not observed between BALB/c mice and C57BL/6J mice. In comparison with gadofluorine M, clearances from the blood, liver, and kidney were more rapid and contrast enhancement in the spleen was generally lower for gadofluorine P. The enhancement in the gallbladder cavity, indicating biliary excretion, was evident only after gadofluorine P injection. Blood enhancement at 10 min was much weaker for gadopentetate dimeglumine. CONCLUSION: Both gadofluorine M and gadofluorine P appear to be applicable to blood pool imaging and liver imaging in mice.
Fugeng Sheng; Yusuke Inoue; Shigeru Kiryu; Makoto Watanabe; Kuni Ohtomo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-2
Journal Detail:
Title:  Japanese journal of radiology     Volume:  -     ISSN:  1867-108X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101490689     Medline TA:  Jpn J Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
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