| Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans. | |
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MedLine Citation:
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PMID: 9264475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ionizing radiation has been shown to reduce neointimal formation after balloon angioplasty in experimental models of restenosis. This study was designed to evaluate the feasibility, safety, and effectiveness of intracoronary radiation therapy (ICRT) after percutaneous transluminal coronary angioplasty (PTCA) for preventing restenosis in human coronary arteries. METHODS AND RESULTS: Twenty-one patients (22 arteries) with unstable angina underwent standard balloon angioplasty. ICRT was performed with the use of an 192Ir source wire that was hand delivered to the angioplasty site. Angiographic follow-up was performed at 24 hours, between 30 and 60 days, and at 6 months. Angioplasty was successful in 19 of 22 lesions, and insertion of the radioactive source wire was successful at all treated sites. Angiographic study at 24 hours demonstrated early late loss of the luminal diameter from 1.92+/-0.55 to 1.40+/-0.27 mm. Between 30 and 60 days, repeat angiography demonstrated total occlusion in 2 arteries, a new pseudoaneurysm in 1 artery, and significant dilatation at the treatment site in 2 additional vessels. At > or = 6 months' follow-up, all remaining arteries (n=20) maintained patent, with a mean lumen diameter of 1.65+/-0.8 mm. The calculated late lumen loss was 0.27+/-0.56 mm, and the late loss index was 0.19. Clinical events at 1 year included myocardial infarction in 1 patient, repeat angioplasty to the treated site in 3 patients, and persistent angina in 7 patients. CONCLUSIONS: These preliminary results demonstrate that ICRT after coronary intervention is feasible and is associated with an acceptable degree of complications and lower rates of angiographic restenosis indexes. |
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Authors:
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J A Condado; R Waksman; O Gurdiel; R Espinosa; J Gonzalez; B Burger; G Villoria; H Acquatella; I R Crocker; K B Seung; S F Liprie |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Circulation Volume: 96 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-15 Completed Date: 1997-09-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 727-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Hospital Miguel Perez-Carrefio, Centro Medico Caracas, Venezuela. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angina, Unstable / therapy* Angioplasty, Transluminal, Percutaneous Coronary* Brachytherapy* Cohort Studies Coronary Angiography* Coronary Disease / prevention & control, therapy* Coronary Vessels / radiation effects* Feasibility Studies Female Follow-Up Studies Humans Male Middle Aged Recurrence Survival Analysis Time Factors Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Circulation. 1997 Aug 19;96(4):1067-8
[PMID:
9286927
]
Circulation. 1999 Aug 24;100(8):780-2 [PMID: 10458709 ] Circulation. 1997 Aug 5;96(3):709-12 [PMID: 9264470 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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