Document Detail

Long-term angiogenic activity of free grafts and pedicle flap in a rabbit urethroplasty model.
MedLine Citation:
PMID:  22544339     Owner:  NLM     Status:  Publisher    
PURPOSE: We studied the late angiogenic activity of free grafts and a pedicle flap in a rabbit urethroplasty model to determine whether angiogenic activity plays a role in late outcomes of urethral reconstruction in rabbits. METHODS: Twenty-eight rabbits were randomly divided into five groups according to the method used to bridge a urethral defect as an onlay patch: Control, simple closure of urethral defect (Group O(1)); free penile skin graft (FPSG, Group A(1)); buccal mucosal graft (BuMG, Group B(1)); bladder mucosal graft (BlMG, Group C(1)); and pedicle penile skin flap (PPSF, Group D(1)). Angiogenic activity of the patch on postoperative day 84 was assessed by immunohistochemistry. RESULTS: The angiogenic activity in Groups O(1), A(1), B(1), C(1), and D(1) was 23.33 ± 4.92 (means ± SD), 42.89 ± 6.52, 55.78 ± 3.46, 53.61 ± 6.17, and 24.11 ± 9.07 vessels per optical field, respectively. There were statistically significant differences (p < .001) between Group O(1) and A(1) B(1), C(1), Group A(1) and B(1), C(1), D(1), Groups B(1) and D(1) and Groups C(1) and D(1), but not between Groups O(1) and D(1) (p = 1.000) and Groups B(1) and C(1) (p = .872). The long-term angiogenic activity of all the groups was significantly lower (p < .001) than in the corresponding early groups. CONCLUSIONS: Although the angiogenic activity of all the groups decreased in the late assessment, the buccal mucosal graft continued to exhibit elevated angiogenesis above bladder or skin (free or pedicle) graft. Therefore, buccal mucosal patch graft might be preferable because of its easier harvesting.
George Vaos; Stefanos Gardikis; Alexandra Giatromanolaki; Katerina Kambouri; Grigorios Trιpsianis; Petros Ypsilantis; Efthimios Sivridis; Constantinos Simopoulos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-28
Journal Detail:
Title:  World journal of urology     Volume:  -     ISSN:  1433-8726     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307716     Medline TA:  World J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatric Surgery, Alexandroupolis University Hospital, Democritus University of Thrace School of Medicine, 68100, Alexandroupolis, Greece,
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