| Long-term alpha 1 blockade does not reverse cardiac hypertrophy in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 8103807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Not all antihypertensive drugs induce regression of left ventricular (LV) hypertrophy in hypertension, although they may equally lower blood pressure. The effects of alpha 1-blockers on regression have been inconsistent. In this study, bunazosin, a selective alpha 1-blocker, (15 mg/kg/day in food) was given to male spontaneously hypertensive rats (SHR) from 15 to 35 weeks of age to evaluate its effects on cardiac hypertrophy, hemodynamics, and neurohumoral factors. Age- and sex-matched SHR served as controls. LV function and cardiac output were determined by a micromanometer and thermodilution, respectively. Bunazosin significantly decreased blood pressure in conscious rats (from 209 to 192 mmHg, p < 0.01) but did not reduce LV mass. Heart rate, LV end-diastolic pressure, dp/dtmax, and cardiac output were similar in the 2 groups. Plasma renin activity was unaltered but plasma norepinephrine levels were higher in the treated rats (p < 0.05). Thus, bunazosin produced a significant relative reduction of blood pressure but did not reverse LV hypertrophy in SHR. Inadequate afterload reduction (8%) due to severe hypertension (> 200 mmHg) may explain the absence of regression. The rise of plasma norepinephrine levels may also offset the beneficial effects of bunazosin. |
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Authors:
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H Nishimura; J Kubota; M Okabe; M Ueyama; T Oka; K Kawamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 57 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-10-12 Completed Date: 1993-10-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 898-903 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Osaka Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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administration & dosage*,
pharmacology Animals Hemodynamics / drug effects Hypertension / complications* Hypertrophy, Left Ventricular / drug therapy* Male Norepinephrine / blood Quinazolines / administration & dosage*, pharmacology Rats Rats, Inbred SHR Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Quinazolines; 51-41-2/Norepinephrine; 80755-51-7/bunazosin; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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