| Long-term airway morbidity following viral LRTI in early infancy: recurrent wheezing or asthma? | |
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MedLine Citation:
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PMID: 19651399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Episodes of lower respiratory illnesses (LRIs) in the first years of life have been associated with recurrent wheeze in studies of high-risk and community-based cohorts. Respiratory syncytial virus (RSV) is an agent especially associated with severe cases of bronchiolitis affecting young infants in winter months and has a typical seasonal pattern. Data from the Children's Respiratory Study from Arizona and a hospital-based Swedish study have been interpreted as evidence that severe RSV bronchiolitis is associated with a 30-40% likelihood of subsequent asthma. Other respiratory viruses, especially Rhinovirus, have been identified to be importantly associated with recurrent wheeze in children at risk for asthma. A case-control study of palivizumab given in the first year of life to preterm infants has shown a 50% reduction in the occurrence of recurrent wheeze even after controlling for potential confounding variables. Prospective trials with anti-viral strategies, including potential new vaccines, should give us better understanding of the role of viral infections in early life in the causation of childhood asthma. |
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Authors:
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Renato T Stein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Paediatric respiratory reviews Volume: 10 Suppl 1 ISSN: 1526-0550 ISO Abbreviation: Paediatr Respir Rev Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-08-04 Completed Date: 2009-11-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100898941 Medline TA: Paediatr Respir Rev Country: England |
Other Details:
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Languages: eng Pagination: 29-31 Citation Subset: IM |
Affiliation:
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Departamento de Pediatria, Faculdade de Medicina, Pontificia Universidade Catolica, Porto Alegre, Brazil. rstein@pucrs.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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epidemiology*,
etiology Bronchiolitis / complications*, virology Humans Infant Morbidity / trends Prognosis Recurrence Respiratory Sounds / etiology* Respiratory Syncytial Virus Infections / complications*, virology Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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