| Long-term air pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan. | |
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MedLine Citation:
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PMID: 20833756 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objectives To investigate changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation associated with changes in long-term exposure to ambient air pollutants. Methods We conducted secondary analyses of data on blood pressure and blood biochemistry markers from the Social Environment and Biomarkers of Aging Study in Taiwan and air pollution data from the Taiwan Environmental Protection Administration in 2000. Associations of 1-year averaged criteria air pollutants (particulate matter with aerodynamic diameters <10 μm (PM(10)) and <2.5 μm (PM(2.5)), ozone (O(3)), nitrogen dioxide (NO(2)), sulfur dioxide and carbon monoxide) with systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting glucose, haemoglobin A1c (HbA1c), interleukin 6 (IL-6) and neutrophils were explored by applying generalised additive models. Results After controlling for potential confounders, we observed that increased 1-year averaged particulate air pollutants (PM(10) and PM(2.5)) and NO(2) were associated with elevated blood pressure, total cholesterol, fasting glucose, HbA1c, IL-6 and neutrophils. Associations of increased 1-year averaged O(3) with elevated blood pressure, total cholesterol, fasting glucose, HbA1c and neutrophils were also observed. In particular, our two-pollutant models showed that PM(2.5) was more significantly associated with end-point variables than two gaseous pollutants, O(3) and NO(2). Conclusions Changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation are associated with long-term exposure to ambient air pollutants. This might provide a link between air pollution and atherosclerotic cardiovascular diseases. |
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Authors:
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Kai-Jen Chuang; Yuan-Horng Yan; Shu-Yi Chiu; Tsun-Jen Cheng |
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Publication Detail:
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Type: Journal Article Date: 2010-09-10 |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 68 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 64-8 Citation Subset: IM |
Affiliation:
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National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, No. 17 Xu-Zhou Road, Zhongzheng District, Taipei 10055, Taiwan; tcheng@ntu.edu.tw. |
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