Document Detail


Long-term administration of pegylated recombinant human megakaryocyte growth and development factor dramatically improved cytopenias in a patient with myelodysplastic syndrome.
MedLine Citation:
PMID:  12930386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To date, there are no curative therapeutic options for patients with myelodysplastic syndromes (MDS) other than allogeneic stem cell transplantation. We treated an MDS patient with 10 microg/kg pegylated recombinant human megakaryocyte growth and development factor (rHuMGDF) for more than 450 d. The patient's platelet counts increased from <10 x 10(9)/l to 50 x 10(9)/l. Interestingly, haemoglobin levels increased dramatically and reached over 13 g/dl without additional transfusion. Adverse events and neutralizing antibodies were not observed during treatment, suggesting that the long-term administration of rHuMGDF might be of clinical benefit to patients with MDS.
Authors:
Masahiro Kizaki; Yoshitaka Miyakawa; Yasuo Ikeda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  122     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-21     Completed Date:  2003-10-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  764-7     Citation Subset:  IM    
Affiliation:
Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. makizaki@sc.itc.keio.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Marrow Cells / pathology
Female
Hemoglobins / analysis
Humans
Myelodysplastic Syndromes / blood,  pathology,  therapy*
Platelet Count
Polyethylene Glycols / therapeutic use*
Recombinant Proteins / therapeutic use*
Thrombopoietin / therapeutic use*
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Polyethylene Glycols; 0/Recombinant Proteins; 0/polyethylene glycol-recombinant human megakaryocyte growth and development factor; 9014-42-0/Thrombopoietin
Comments/Corrections
Comment In:
Br J Haematol. 2004 Jun;125(6):818-9   [PMID:  15180875 ]

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