| Long-term administration of Polygonum multiflorum Thunb. reduces cerebral ischemia-induced infarct volume in gerbils. | |
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MedLine Citation:
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PMID: 12723756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Focal cerebral ischemia was produced by an occlusion of the middle cerebral artery for 1, 3 and 24 hours in gerbils. Infarct volumes were determined by 2,3,5-triphenyltetrazolium chloride (TTC) transcardiac perfusion 24 hours after cerebral ischemia. Significant and consistent infarct sizes were produced in gerbils subjected to 24-hour occlusion of the middle cerebral arterey when compared to the 1 and 3-hour occlusion group. Longterm pretreatment of the 50% ethanol extract of Polygonum multiflorum Thunb. for 2 weeks significantly reduced the infarct volume by 50% as compared to that of the 24-hour occlusion group. The results revealed that long term pretreatment of Polygonum multiflorum Thunb. may protect the brain against focal cerebral ischemia. |
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Authors:
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Yin-Ching Chan; Ming-Fu Wang; Ya-Ching Chen; Dar-Yu Yang; Ming-Shih Lee; Fu-Chou Cheng |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of Chinese medicine Volume: 31 ISSN: 0192-415X ISO Abbreviation: Am. J. Chin. Med. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-05-01 Completed Date: 2003-09-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7901431 Medline TA: Am J Chin Med Country: United States |
Other Details:
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Languages: eng Pagination: 71-7 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Providence University, Taichung, 433 Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / physiopathology, prevention & control* Drugs, Chinese Herbal / pharmacology* Gerbillinae Infarction, Middle Cerebral Artery / pathology Male Motor Activity / physiology Neuroprotective Agents / pharmacology* Plant Roots Polygonum* Random Allocation Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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