Document Detail

Long-term acyclovir prophylaxis in bone marrow transplant recipients and lymphocyte proliferation responses to herpes virus antigens in vitro.
MedLine Citation:
PMID:  2844333     Owner:  NLM     Status:  MEDLINE    
In this randomized double-blind and placebo controlled trial of 6 months' prophylaxis with acyclovir (ACV) in 42 bone marrow transplant (BMT) recipients, patients receiving ACV had fewer herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections during the prophylaxis compared to the placebo treated patients (P less than 0.05). During the first 6 months after the prophylaxis had been discontinued the frequency of clinical HSV reactivations was low both in the ACV (1/13) and in the placebo (1/13) treated patient groups. Altogether the ACV treated patients had significantly fewer HSV reactivations during the first year after BMT (P less than 0.05). The HSV-specific lymphocyte proliferation response was also lower in the ACV treated group at 3, 6 and 12 months after BMT (P less than 0.05). VZV infections recurred rather frequently, however, after discontinuation of ACV prophylaxis. Therefore no difference was found in the number of VZV infections during the first year after BMT. The VZV-specific lymphocyte proliferation response was significantly lower in the ACV treated group only at 6 months (P less than 0.05). ACV prophylaxis had no effect on the frequency of CMV infections; CMV-specific lymphocyte proliferative responses were not decreased.
P Ljungman; H Wilczek; G Gahrton; A Gustavsson; G Lundgren; B Lönnqvist; O Ringdén; B Wahren
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  1     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1988-11-15     Completed Date:  1988-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
Department of Medicine, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Actuarial Analysis
Acyclovir / therapeutic use*
Antigens, Viral / immunology
Bone Marrow Transplantation*
Cell Transformation, Viral / drug effects*
Child, Preschool
Clinical Trials as Topic
Double-Blind Method
Graft vs Host Disease / etiology
Herpes Simplex / etiology
Lymphocyte Activation / drug effects*
Random Allocation
Simplexvirus / immunology*
Reg. No./Substance:
0/Antigens, Viral; 59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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