Document Detail

Long-term acid-base measurements in the fetal and maternal baboon.
MedLine Citation:
PMID:  1536256     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of the study was to examine the relationship between maternal and fetal acid-base indexes in the baboon. STUDY DESIGN: Eight animals maintained in a tether system were studied during the third trimester. Results were analyzed using analysis of variance. RESULTS: After recovery from surgery, pH in carotid artery blood of the fetus was 7.40 +/- 0.027 (mean +/- SD), PO2, 27.5 +/- 3.45 mm Hg; PCO2, 34.0 +/- 2.37 mm Hg; base deficit, 3.0 +/- 2.15 mEq/L; Hot, 33.4% +/- 2.69% and HbO2, 61.3% +/- 8.65%. The corresponding values in the mother were 7.48 +/- 0.035, 100.7 +/- 9.44 mm Hg, 26.4 +/- 2.95 mm Hg, 3.6 +/- 1.71 mEq/L, 32.6% +/- 4.0% and 97.9% +/- 1.28%, respectively. All indexes remained essentially the same until the onset of active labor, at which time the fetus became slightly acidotic and hypoxemic (pH less than 7.35, HbO2 less than 50%). CONCLUSION: The baboon fetus has slightly higher pH2 and lower PaCO2 than the human fetus and PaO2, base deficit, and maternal-fetal gradients across the placenta in these two primate species are comparable.
S S Daniel; L S James; G MacCarter; H O Morishima; R I Stark
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  166     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-20     Completed Date:  1992-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  707-12     Citation Subset:  AIM; IM    
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
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MeSH Terms
Acid-Base Equilibrium*
Analysis of Variance
Blood Gas Analysis
Carbon Dioxide / blood
Fetal Blood / metabolism*
Hydrogen-Ion Concentration
Oxygen / blood
Pregnancy, Animal / blood*
Time Factors
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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