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Long-term Ultrasonographic Follow-up Study of Gastric Motility in Patients with Functional Dyspepsia.
MedLine Citation:
PMID:  18385832     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Although patients with functional dyspepsia complain of epigastric symptoms, the relation between these symptoms and gastric motility remains controversial. There are few reports on the clinical course of functional dyspepsia, including changes in gastric motility, observed over a considerably long period. We conducted a study to examine association between changes in symptoms and changes in ultrasonographically evaluated gastric motility over a long-term follow-up period in patients with functional dyspepsia. Forty patients (18 men, 22 women; mean age, 53.7 years) with functional dyspepsia were followed up by medical interview, physical examination, endoscopy, and ultrasonography for gastric motility. Follow-up ranged from 1.0 to 7.8 years (mean, 3.0 years). Ultrasonographic evaluation of gastric motility included gastric emptying rate and antral contractions. During the follow-up period, patients were treated with proton pump inhibitors, H2-blockers, or prokinetics. Symptoms improved in 21 patients (group A), but symptoms persisted or worsened in 19 patients (group B). There were no significant differences in clinical characteristics between the two groups. Gastric motility improved in group A but not in group B. In conclusion, improved gastric motility appears to correspond to and may explain improved symptoms in some patients with functional dyspepsia.
Daisuke Kamino; Noriaki Manabe; Jiro Hata; Ken Haruma; Shinji Tanaka; Kazuaki Chayama
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical biochemistry and nutrition     Volume:  42     ISSN:  0912-0009     ISO Abbreviation:  J Clin Biochem Nutr     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2011-07-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8700907     Medline TA:  J Clin Biochem Nutr     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  -    
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
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