Document Detail

Long-term treatment of renal lithiasis with potassium citrate.
MedLine Citation:
PMID:  20399488     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the urine metabolic changes induced by sustained potassium citrate (KCit) treatment in patients with either hypocitraturia (HCit) or "unduly acidic urine pH" (UAUpH), and to determine the remission rate in those patients treated for more than 24 months.
METHODS: We retrospectively reviewed the charts of 215 adult patients with recurrent renal stones whose only urinary metabolic risk factors were either HCit (n = 95) or UAUpH (n = 120) and had been treated with KCit for more than 3 months.
RESULTS: In patients with Hcit (55 men and 40 women, mean age was 43 ± 14 years), Kcit therapy (average dose 48 ± 14.7 mEq/d) caused a sustained increase in urinary citrate to normal levels, in urinary potassium and pH and in serum potassium. In patients with UAUpH (73 men and 47 women; mean age 48.7 ± 12 years), Kcit therapy (average dose 42.8 ± 15.5 mEq/d) produced a significant increase in urinary pH, potassium, and uric acid. Remission rate was studied in 35 of these patients, whose median follow-up of 31.6 ± 14.3 months. All of these patients received a mean dose of potassium citrate of 45.4 ± 15.2 mEq/d. In 91% of these patients, there was no stone recurrence, similar for Hcit and UAUpH patients.
CONCLUSIONS: Treatment with potassium citrate corrects the metabolic abnormalities seen in patients with Hcit and UAUpH. This was associated with a very high remission rate of stone disease.
Francisco R Spivacow; Armando L Negri; Ana Polonsky; Elisa E Del Valle
Related Documents :
3589528 - Transluminal balloon dilation of ureteral stricture in a child. a case report.
3992768 - Pain control: comparison of percutaneous and operative nephrolithotomy.
10805838 - Long-term outcome of endoscopic papillotomy for choledocholithiasis with cholecystolith...
16806418 - Percutaneous suprapubic cystolithotripsy under local anesthesia.
19730008 - Polyester connecting ring improves outcome in nitinol composite artificial esophagus.
23036228 - Ldl-apheresis dramatically improves generalized calciphylaxis in a patient undergoing h...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology     Volume:  76     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1346-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Instituto de Investigaciones Metabólicas, Universidad del Salvador, Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Citric Acid / urine
Drug Evaluation
Gastrointestinal Diseases / chemically induced
Hydrogen-Ion Concentration
Middle Aged
Nephrolithiasis / drug therapy*
Potassium Citrate / administration & dosage,  adverse effects,  therapeutic use*
Recurrence / prevention & control
Remission Induction
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Urine / chemistry
Young Adult
Reg. No./Substance:
6100-05-6/Potassium Citrate; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Novel Concentrated Cranberry Liquid Blend, UTI-STAT With Proantinox, Might Help Prevent Recurrent Ur...
Next Document:  Incidental ureteral catheterization with cystometry catheter during video urodynamics: a prompt diag...