Document Detail


Long-term treatment of renal lithiasis with potassium citrate.
MedLine Citation:
PMID:  20399488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the urine metabolic changes induced by sustained potassium citrate (KCit) treatment in patients with either hypocitraturia (HCit) or "unduly acidic urine pH" (UAUpH), and to determine the remission rate in those patients treated for more than 24 months.
METHODS: We retrospectively reviewed the charts of 215 adult patients with recurrent renal stones whose only urinary metabolic risk factors were either HCit (n = 95) or UAUpH (n = 120) and had been treated with KCit for more than 3 months.
RESULTS: In patients with Hcit (55 men and 40 women, mean age was 43 ± 14 years), Kcit therapy (average dose 48 ± 14.7 mEq/d) caused a sustained increase in urinary citrate to normal levels, in urinary potassium and pH and in serum potassium. In patients with UAUpH (73 men and 47 women; mean age 48.7 ± 12 years), Kcit therapy (average dose 42.8 ± 15.5 mEq/d) produced a significant increase in urinary pH, potassium, and uric acid. Remission rate was studied in 35 of these patients, whose median follow-up of 31.6 ± 14.3 months. All of these patients received a mean dose of potassium citrate of 45.4 ± 15.2 mEq/d. In 91% of these patients, there was no stone recurrence, similar for Hcit and UAUpH patients.
CONCLUSIONS: Treatment with potassium citrate corrects the metabolic abnormalities seen in patients with Hcit and UAUpH. This was associated with a very high remission rate of stone disease.
Authors:
Francisco R Spivacow; Armando L Negri; Ana Polonsky; Elisa E Del Valle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology     Volume:  76     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1346-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Instituto de Investigaciones Metabólicas, Universidad del Salvador, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Adult
Citric Acid / urine
Drug Evaluation
Female
Gastrointestinal Diseases / chemically induced
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Nephrolithiasis / drug therapy*
Potassium Citrate / administration & dosage,  adverse effects,  therapeutic use*
Recurrence / prevention & control
Remission Induction
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Urine / chemistry
Young Adult
Chemical
Reg. No./Substance:
6100-05-6/Potassium Citrate; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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