Document Detail

Long-term outcomes of exercise: follow-up of a randomized trial in older women with osteopenia.
MedLine Citation:
PMID:  20876406     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Long-term evidence from randomized trials of the effectiveness of exercise in preventing disability and fall-related fractures in elderly people has been lacking. METHODS: We performed extended follow-up of 160 women (aged 70-73 years at baseline) with osteopenia in a population-based, randomized, controlled exercise trial. The trial was conducted from April 1 through April 30, 2001. Follow-up was conducted from May 1, 2001, through December 31, 2005. Mean total time in observation was 7.1 years. Primary outcome measures were femoral neck bone mineral density, postural sway, and leg strength. Secondary outcome measures were hospital-treated fractures and functional ability measures. Outcomes were measured annually using masked assessors. RESULTS: There was a significant difference between groups in favor of exercise in terms of postural sway (group × time interaction, P = .005), walking speed (group × time interaction, P < .001), and Frenchay Activities Index score (group x time interaction, P = .001). The bone mineral density decreased similarly across time in both groups. The incidence rate of fractures during the total follow-up among women in the exercise group vs women in the control group was 0.05 vs 0.08 per 1000 person-years (Poisson incidence rate ratio, 0.68; 95% confidence interval, 0.34-1.32). There were no hip fractures in the exercise group, whereas 5 hip fractures occurred in the control group. One woman in the exercise group and 8 women in the control group died (Poisson incidence rate ratio, 0.11; 95% confidence interval, 0.01-0.85). CONCLUSION: Mainly home-based exercises followed by voluntary home training seem to have a long-term effect on balance and gait and may even protect high-risk elderly women from hip fractures. TRIAL REGISTRATION: Identifier: NCT00655577.
Raija Korpelainen; Sirkka Keinänen-Kiukaanniemi; Pentti Nieminen; Jorma Heikkinen; Kalervo Väänänen; Juha Korpelainen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of internal medicine     Volume:  170     ISSN:  1538-3679     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1548-56     Citation Subset:  AIM; IM    
Department of Sports and Exercise Medicine, Oulu Deaconess Institute, 90100 Oulu, Finland.
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MeSH Terms
Accidental Falls / prevention & control
Bone Density*
Bone Diseases, Metabolic / rehabilitation*
Confidence Intervals
Follow-Up Studies
Fractures, Bone / prevention & control
Hip Fractures / prevention & control
Life Style
Osteoporosis, Postmenopausal / rehabilitation
Physical Fitness*
Quality of Life
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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