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The Long-term Outcome Predictors of Pure Microvascular Decompression for Primary Trigeminal Neuralgia.
MedLine Citation:
PMID:  22381868     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study is to provide credible and comparable evidence on the efficacy and safety of pure MVD for primary TN, and also to find out the possible prognostic factors of excellent long-term outcome after the surgery. METHOD: A prospective cohort study was conducted, involving the patients who met the diagnostic criteria of primary TN (both typical and atypical). The cohort patients underwent pure MVD, and then were followed up by independent neurologists. The possible prognostic factors were analyzed via Logistic method. RESULT: All 154 consecutive primary TN patients (98 typical cases, 56 atypical cases) underwent pure MVD from January 2001 to November 2005. The patients were followed up for median 5.6 years (10 lost in 5 years). Respective initial and 5-year's complete pain-free without medication (BNI pain scored I) rates were 84% and 72% for total primary TN, 87% and 80% for typical TN, while 79% and 54% for atypical TN. The Kaplan-Meier survival curves of 5 years demonstrated different long-term outcomes in different groups (typical TN vs. atypical TN). The typical symptoms (OR 2.776), preoperative MR indicating vessel compression (OR 2.950), and obvious vessel compression found during operation (OR 3.219) were proved having positive effect on long-term pain relief without medication. CONCLUSION: This is a perspective cohort study of pure MVD, which confirms the long-term effectiveness and safety of the surgery for primary TN. Patients with typical symptoms, positive MR findings, or obvious vessel compressions might have better long-term prognosis.
Authors:
Heng Zhang; Ding Lei; Chao You; Bo-Yong Mao; Bo Wu; Yuan Fang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-26
Journal Detail:
Title:  World neurosurgery     Volume:  -     ISSN:  1878-8750     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528275     Medline TA:  World Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
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