Document Detail


Long-term Mild Exercise Training Enhances Hippocampus-dependent Memory in Rats.
MedLine Citation:
PMID:  25429548     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although exercise training improves hippocampus-related cognition, the optimum exercise intensity is still disputed. Based on the lactate threshold (LT, approximately 20 m/min on treadmill) of rats, we have shown that 2 weeks of training with stress-free mild exercise (ME, <LT), but not intense exercise (IE, >LT), comprising exercise stress, promotes adult hippocampal neurogenesis (Okamoto et al., PNAS, 2012), a potential substrate for memory improvement. These results led us to postulate that long-term ME, but not IE, training leads to improved hippocampal function as assessed with a Morris water maze (MWM) task. To test this hypothesis, we investigated the changes in physiological stress levels and MWM task performance in rats assigned to 6 weeks of sedentary control (CONT), ME-training or IE-training conditions. Results showed that, compared to the other conditions, only IE causes general adaptive syndrome (GAS), including adrenal hypertrophy, thymic atrophy and hypercorticosteronemia. In the MWM, ME led to enhanced memory, but not learning, compared with CONT, while IE produced no change in either capacity, probably due to GAS. These findings support the hypothesis that 6 weeks of continuous ME training leads to enhanced hippocampus-related memory, which may have implications for both healthy adults and subjects with low physical capacity.
Authors:
K Inoue; Y Hanaoka; T Nishijima; M Okamoto; H Chang; T Saito; H Soya
Related Documents :
10333898 - Prediction of cardiovascular events in clinically selected high-risk niddm patients. pr...
8921788 - Prolonged impairment of regional contractile function after resolution of exercise-indu...
3898798 - Comparison of stress digital ventriculography, stress thallium scintigraphy, and digita...
8869118 - Functional evaluation of patients with coronary artery disease: selection of appropriat...
9851848 - The differential sensitivities of inner ear structures to retinoic acid during developm...
24501378 - Effect of a 12-month exercise intervention on serum biomarkers of angiogenesis in postm...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-27
Journal Detail:
Title:  International journal of sports medicine     Volume:  -     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Exercise Effects on Erythrocyte Deformability in Exercise-induced Arterial Hypoxemia.
Next Document:  Cardiovascular Responses during Free-Diving in the Sea.