| Long-term MR imaging course of neurodegenerative Langerhans cell histiocytosis. | |
| | |
MedLine Citation:
|
PMID: 17569949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: MR imaging signal intensity abnormalities in the cerebellum, the pons, and the basal ganglia, compatible with a neurodegenerative process (ND) were reported in up to 10% of patients with Langerhans cell histiocytosis (LCH). Although the imaging features of ND-LCH have been extensively described, the temporal course of ND-LCH has not been assessed as of yet. The purpose of this study was to describe the long-term course of MR imaging signal intensity abnormalities in ND-LCH on T1- and T2-weighted images. MATERIALS AND METHODS: In this retrospective study, 9 patients with ND-LCH with an observation time of at least 5 years were included. Three or more MR imaging studies per patient, performed in 3-year intervals (+/-11 months), were reviewed. Signal intensity abnormalities on T1- and T2-weighted images in the cerebellum, the pons, and basal ganglia were scored for their signal intensity quality and their extension. In addition, the severity of cerebellar atrophy was scored. RESULTS: The signal intensity alterations were not resolved in any of the patients. Instead, a progression of the signal intensity alterations either in the cerebellum or basal ganglia was observed in all of the patients but did not correlate with a clinical deterioration. Overt and severe neurologic symptoms were reported in only 2 patients in whom some form of atrophy was noted. CONCLUSIONS: ND-LCH appears to be a slowly progressive process. The increase of signal intensity abnormalities in the cerebellum and basal ganglia does not correlate with neurologic deterioration. MR imaging appears to be a sensitive technique to detect and monitor radiologic ND-LCH. |
| | |
Authors:
|
H Prosch; N Grois; M Wnorowski; M Steiner; D Prayer |
Related Documents
:
|
3662649 - Preliminary observations on the role of magnetic resonance imaging for polymyositis and... 8946539 - Mr imaging of osteomyelitis and neuropathic osteoarthropathy in the feet of diabetics. 9129429 - Resolution of abnormal mr signal intensity in patients with stress fractures of the fem... 20494809 - Comparison of prognostic value of different mri classifications of signal intensity cha... 10204889 - Magnetic resonance imaging of frozen tissues: temperature-dependent mr signal character... 8491909 - Spinal neurilemmomas and neurofibromas: central dot sign in postgadolinium mri. 1324509 - Focal liver disease: comparison of dynamic contrast-enhanced ct and t2-weighted fat-sup... 10508289 - Fast dynamic gadolinium-enhanced mr imaging of urinary bladder and prostate cancer. 22158389 - Osteonecrosis in children after allogeneic hematopoietic cell transplantation: study of... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 28 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2007 Jun-Jul |
Date Detail:
|
Created Date: 2007-06-15 Completed Date: 2007-08-08 Revised Date: 2008-06-24 |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1022-8 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Otto Wagner Hospital, Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Basal Ganglia
/
pathology* Brain Diseases / diagnosis* Cerebellum / pathology* Child Child, Preschool Female Histiocytosis, Langerhans-Cell / diagnosis* Humans Infant Longitudinal Studies Magnetic Resonance Imaging* Male Neurodegenerative Diseases / diagnosis* |
| Comments/Corrections | |
Comment In:
|
AJNR Am J Neuroradiol. 2008 Apr;29(4):e14; author reply e15
[PMID:
18296544
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy t...
Next Document: Correlation of MR imaging and MR spectroscopy findings with cognitive impairment in mucopolysacchari...