Document Detail


Long-term GABA treatment elicits supersensitivity of quisqualate-preferring metabotropic glutamate receptor in cultured rat cerebellar neurons.
MedLine Citation:
PMID:  8101556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In primary cultures of rat cerebellar granule neurons, GABA treatment (50 microM, 7 days) caused a withdrawal supersensitivity selective for the metabotropic glutamate receptors that mainly prefer L-glutamate, quisqualate and, to a lesser extent, kainate. The withdrawal supersensitivity was absent when 10 microM SR-95531 was coadministered with GABA during the treatment period, an event that suggests the GABAA receptors primarily produced the GABA treatment effect. This was supported further by the inability of baclofen treatment to mimic completely the treatment effect of GABA. Withdrawal from 7 days of baclofen treatment only produced a slight increase in the metabotropic effect of L-glutamate and carbachol. In addition, in untreated neurons, baclofen had no acute effect, whereas GABA inhibited the effect of L-glutamate and carbachol. The inhibitory effect of GABA was reversed by SR-95531 and was absent in neurons treated with GABA. These observations suggest the involvement of GABAA receptors and the apparent development of tolerance to GABA, respectively. Also, dependence on GABA may have occurred; the metabotropic effects of glutamate, kainate, and quisqualate were not altered in neurons maintained with GABA treatment.
Authors:
O Yu; D M Chuang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  61     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-08-24     Completed Date:  1993-08-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  430-5     Citation Subset:  IM    
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Baclofen / pharmacology
Carbachol / pharmacology
Cells, Cultured
Cerebellum / metabolism*
Drug Tolerance
Glutamates / pharmacology
Glutamic Acid
Kainic Acid / pharmacology
N-Methylaspartate / pharmacology
Neurons / metabolism*
Potassium Chloride / pharmacology
Pyridazines / pharmacology
Quisqualic Acid / metabolism*
Rats
Rats, Sprague-Dawley
Receptors, GABA-A / antagonists & inhibitors,  physiology
Receptors, Glutamate / drug effects,  metabolism*
gamma-Aminobutyric Acid / pharmacology*
Chemical
Reg. No./Substance:
0/Glutamates; 0/Pyridazines; 0/Receptors, GABA-A; 0/Receptors, Glutamate; 104104-50-9/gabazine; 1134-47-0/Baclofen; 487-79-6/Kainic Acid; 51-83-2/Carbachol; 52809-07-1/Quisqualic Acid; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 6384-92-5/N-Methylaspartate; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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