| A long-term follow-up of serum myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease treated with propylthiouracil. | |
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MedLine Citation:
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PMID: 19851036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Propylthiouracil (PTU) is known to induce myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease (GD). Previously, we showed that serum MPO-ANCA were frequently seen in patients with GD treated with PTU. In this study, we analyzed 13 patients with positive MPO-ANCA examining a long-term clinical consequence of these patients as well as antibody titers during 5.6 +/- 3.0 years. PTU therapy was continued in 8 patients and discontinued in 5 patients. Antibody titers decreased in 7 of 8 patients who discontinued PTU therapy but remained positive in 5 patients 5 years after PTU withdrawal. The initial MPO-ANCA levels were significantly higher in those antibody titers remained positive for longer than 5 years (n=5) than in those titers turned to be negative within 5 years after PTU withdrawal (n=3) (203 +/- 256 EU and 22 +/- 2 EU, respectively, P=0.04), but there were no significant differences in age, gender, duration of PTU therapy or dosage of PTU. Among 5 patients who continued PTU therapy, 2 patients with initially low MPO-ANCA titers turned to having negative antibody. No patients had new symptoms or signs of vasculitis throughout the follow-up periods. The long-term follow-up study suggests that higher MPO-ANCA levels remain positive for years after PTU withdrawal but are rarely associated with vasculitis. |
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Authors:
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Reiko Ishii; Misa Imaizumi; Akane Ide; Nobuko Sera; Ikuko Ueki; Ichiro Horie; Takao Ando; Toshiro Usa; Eri Ejima; Kiyoto Ashizawa; Katsumi Eguchi |
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Publication Detail:
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Type: Journal Article Date: 2009-10-23 |
Journal Detail:
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Title: Endocrine journal Volume: 57 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 73-9 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Antineutrophil Cytoplasmic / blood* Antithyroid Agents / adverse effects, therapeutic use* Female Follow-Up Studies Graves Disease / blood, drug therapy*, enzymology, immunology* Humans Male Middle Aged Peroxidase / antagonists & inhibitors, immunology* Propylthiouracil / adverse effects, therapeutic use* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Antithyroid Agents; 51-52-5/Propylthiouracil; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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