| Long-term clinical significance of thyroid autoimmunity in children with celiac disease. | |
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MedLine Citation:
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PMID: 19846116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the long-term outcome of thyroid function and autoimmunity in a large series of children with celiac disease. STUDY DESIGN: This longitudinal, retrospective study (duration of follow-up, 8.9 +/- 4.0 years) was conducted at the Pediatric Department, University of Bologna, Italy. One hundred thirty-five consecutive patients diagnosed between June 1990 and December 2004 and followed on a gluten-free diet were examined. Inclusion criteria were good dietary compliance and duration of follow-up for at least 3 years. RESULTS: Of 101 patients who never showed positive antithyroid titers during the follow-up, 86 remained euthyroid; 15 showed high thyroid-stimulating hormone values at diagnosis that normalized in 11 cases after 12 to 18 months of gluten withdrawal. Of 31 patients with persistently positive antibody titers, 23 (74%) remained consistently euthyroid during the follow-up and 8 (26%) had a subclinical hypothyroidism. The prevalence of cases with positive antibodies was similar in children with growth retardation or gastroenterological symptoms at diagnosis and different durations of gluten exposure. CONCLUSIONS: The presence of antithyroid antibodies in children with celiac disease has a low predictive value for the development of thyroid hypofunction during the indicated surveillance period. Longer follow-up is needed. |
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Authors:
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Alessandra Cassio; Giampaolo Ricci; Federico Baronio; Angela Miniaci; Milva Bal; Barbara Bigucci; Veronica Conti; Alessandro Cicognani |
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Publication Detail:
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Type: Journal Article Date: 2009-10-20 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 156 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 292-5 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. alessandra.cassio@unibo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Autoantibodies / blood Celiac Disease / epidemiology*, immunology Child Child, Preschool Female Follow-Up Studies Gastrointestinal Diseases / epidemiology, immunology Growth Disorders / epidemiology, immunology Humans Hypothyroidism / epidemiology, immunology Italy / epidemiology Male Peroxidase / immunology Prevalence Retrospective Studies Thyroglobulin / immunology Thyroiditis, Autoimmune / epidemiology*, immunology, prevention & control Thyrotropin / blood |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin; EC 1.11.1.7/Peroxidase |
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