Document Detail

Long-term clinical significance of thyroid autoimmunity in children with celiac disease.
MedLine Citation:
PMID:  19846116     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the long-term outcome of thyroid function and autoimmunity in a large series of children with celiac disease. STUDY DESIGN: This longitudinal, retrospective study (duration of follow-up, 8.9 +/- 4.0 years) was conducted at the Pediatric Department, University of Bologna, Italy. One hundred thirty-five consecutive patients diagnosed between June 1990 and December 2004 and followed on a gluten-free diet were examined. Inclusion criteria were good dietary compliance and duration of follow-up for at least 3 years. RESULTS: Of 101 patients who never showed positive antithyroid titers during the follow-up, 86 remained euthyroid; 15 showed high thyroid-stimulating hormone values at diagnosis that normalized in 11 cases after 12 to 18 months of gluten withdrawal. Of 31 patients with persistently positive antibody titers, 23 (74%) remained consistently euthyroid during the follow-up and 8 (26%) had a subclinical hypothyroidism. The prevalence of cases with positive antibodies was similar in children with growth retardation or gastroenterological symptoms at diagnosis and different durations of gluten exposure. CONCLUSIONS: The presence of antithyroid antibodies in children with celiac disease has a low predictive value for the development of thyroid hypofunction during the indicated surveillance period. Longer follow-up is needed.
Alessandra Cassio; Giampaolo Ricci; Federico Baronio; Angela Miniaci; Milva Bal; Barbara Bigucci; Veronica Conti; Alessandro Cicognani
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Publication Detail:
Type:  Journal Article     Date:  2009-10-20
Journal Detail:
Title:  The Journal of pediatrics     Volume:  156     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Department of Pediatrics, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy.
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MeSH Terms
Autoantibodies / blood
Celiac Disease / epidemiology*,  immunology
Child, Preschool
Follow-Up Studies
Gastrointestinal Diseases / epidemiology,  immunology
Growth Disorders / epidemiology,  immunology
Hypothyroidism / epidemiology,  immunology
Italy / epidemiology
Peroxidase / immunology
Retrospective Studies
Thyroglobulin / immunology
Thyroiditis, Autoimmune / epidemiology*,  immunology,  prevention & control
Thyrotropin / blood
Reg. No./Substance:
0/Autoantibodies; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin; EC

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