Document Detail

Long-term clinical outcomes of drug-eluting stents vs bare-metal stents in Chinese patients.
MedLine Citation:
PMID:  20556818     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is limited data on the magnitude of the problem of drug-eluting stent (DES) thrombosis in the Asian population. HYPOTHESIS: We evaluated the long-term clinical outcomes of DES vs bare metal stents (BMS) in Chinese patients. METHODS: From January 2002 to October 2005, 1236 consecutive patients underwent percutaneous coronary intervention with DES or BMS coronary stent implantation at our institution. We analyzed major clinical end points like all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis. RESULTS: The 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (3.4%, 0.9%, 3.6%) when compared with the BMS group (7.5%, 4.4%, 6.2%; P < .05). No significant differences were found in the 3-year cumulative rates for TLR or stent thrombosis when comparing the DES group (8.3%, 1.63%) vs the BMS group (9.6%, 1.6%; P > .05). However, after 1 year, there were 8 episodes of stent thrombosis in the DES group vs 1 episode of stent thrombosis in the BMS group (P = .04). CONCLUSION: Drug-eluting stents are associated with a significant reduction in the 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction when compared to BMS. However, there were no significant differences in the cumulative rates of TLR or stent thrombosis at 3 years. Stent thrombosis after 1 year was more common in the DES group, but this did not translate to increased mortality. The suggestion that DES might confer a mortality benefit should be interpreted with caution as there could be several confounding factors that were not identified in our study.
Hee-Hwa Ho; Vincent Pong; Chung-Wah Siu; Man-Hong Jim; Raymond Miu; Kai-Hang Yiu; Ryan Ko; Hung-Fat Tse; On-Hing Kwok; Wing-Hing Chow
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  33     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E22-9     Citation Subset:  IM    
Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects,  instrumentation*,  mortality
Asian Continental Ancestry Group* / statistics & numerical data
Coronary Angiography
Coronary Artery Disease / ethnology*,  mortality,  radiography,  therapy*
Drug-Eluting Stents*
Kaplan-Meiers Estimate
Middle Aged
Myocardial Infarction / ethnology
Proportional Hazards Models
Risk Assessment
Risk Factors
Severity of Illness Index
Thrombosis / ethnology
Time Factors
Treatment Outcome
Reg. No./Substance:

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