Document Detail

Long-term 1,25(OH)2 vitamin D therapy increases bone mineral density in osteopenic women. Comparison with the effect of plain vitamin D.
MedLine Citation:
PMID:  18172369     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Although the bone protective effect of vitamin D has been studied intensively, the usefulness of 1,25(OH)2D3 in treating osteoporosis is still questionable. The aim of the present prospective study was to evaluate the effect of a standard pharmacological dose of 1,25(OH)2D3 in postmenopausal unsubstituted women. METHODS: Our study group comprised 52 post-menopausal women with low normal or osteopenic values of bone mineral density (BMD). Thirty-two of them were treated with 1,25(OH)2D3 for 3 years. In parallel, another group of women was treated with cholecalciferol (n=20). Vitamin D adequacy before administration of 1,25(OH)2D3 and compliance with treatment were checked by serum PTH levels, which were assessed at the start and three times in the course of treatment. RESULTS: Increase in BMD at the spine at the end of the 1st, 2nd and 3rd years of treatment with 1,25(OH)2D3 (expressed as a percentage of the value before treatment) was higher, but did not significantly differ from the effect of plain vitamin D. A significant increase in BMD at the hip at the end of the 3rd (but not the 1st and 2nd) year of treatment with 1,25(OH)2D3 was found (p<0.05, compared with the effect of plain vitamin D). The protective effect of cholecalciferol was found only on spine but not hip BMD. CONCLUSION: The study supports the hypothesis that long-term administration of 1,25(OH)2D3 is effective in treating low bone mass in postmenopausal women.
Ivana Zofkova; Martin Hill
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aging clinical and experimental research     Volume:  19     ISSN:  1594-0667     ISO Abbreviation:  Aging Clin Exp Res     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-03     Completed Date:  2008-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101132995     Medline TA:  Aging Clin Exp Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  472-7     Citation Subset:  IM    
Institute of Endocrinology, Prague, Czech Republic.
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MeSH Terms
Bone Density / drug effects*
Bone Density Conservation Agents / pharmacology,  therapeutic use*
Bone Diseases, Metabolic / drug therapy*
Calcitriol / pharmacology,  therapeutic use*
Middle Aged
Vitamin D / pharmacology,  therapeutic use
Reg. No./Substance:
0/Bone Density Conservation Agents; 1406-16-2/Vitamin D; 32222-06-3/Calcitriol

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