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Long-term (12-month) improvement in meibomian gland function and reduced dry eye symptoms with a single thermal pulsation treatment.
MedLine Citation:
PMID:  23145471     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To determine the 1-year post-treatment dry eye status of subjects with meibomian gland dysfunction (MGD) and dry eye symptoms after receiving a single LipiFlow® Thermal Pulsation System (LTPS) treatment. DESIGN: Single-center, prospective, observational, open-label, 1-month registered clinical trial with a 1-year follow-up examination. PARTICIPANTS: Patients with evaporative dry eye disease with MGD and dry eye symptoms who had participated in the registered 1-month clinical trial and who were available for follow-up at 1-year. METHODS: Eighteen of 30 subjects initially enrolled were able to return for a 1-year follow-up. Both eyes of all patients were treated with a single 12-minute treatment using the LTPS that liquefies and expresses the secretory contents of the meibomian glands. Meibomian gland function, tear break-up time (TBUT) and dry eye symptoms were measured. Data are presented for pre-treatment (baseline), and 1-month and 1-year post-treatment. MAIN OUTCOME MEASURES: Meibomian gland secretion scores and TBUT and dry eye symptoms. RESULTS: Significant improvement in meibomian gland secretion scores from baseline measurements (4.0±3.4) to 1-month post-treatment (11.3±4.7;p<0.0005) was maintained at 1-year (7.3±4.6;p<0.05). Baseline TBUT (4.9±3.0) was significantly increased at 1-month (9.5±6.9;p<0.05), however, this improvement was no longer evident at 1-year post-treatment (6.0±4.4). The significant improvement in symptom scores on OSDI and SPEED questionnaires observed at 1-month (p<0.0005) was maintained at 1-year [OSDI (p<0.05); SPEED (p<0.0005)]. CONCLUSION: A single12-minute treatment with the LTPS offers an effective treatment for evaporative dry eye and MGD resulting in significant and sustained improvement in signs and symptoms for up to 1 year.
Authors:
Jack V Greiner
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  -     ISSN:  1442-9071     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Affiliation:
Schepens Eye Research Institute, The Massachusetts Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Boston Ocular Surface Center, Boston & Winchester, MA, USA.
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