Document Detail


Long-pulsed ruby laser for permanent hair reduction: histological analysis after 3, 4 1/2, and 6 months.
MedLine Citation:
PMID:  12116335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: The histology of hair follicles in both animal and human skin treated with ruby lasers has been evaluated to a limited extent in previous studies. We have previously looked at such follicles up to 2 months after treatment. This study examines the longer-term effects at a microscopic level and attempts to further elucidate the mechanism of ruby laser hair reduction. STUDY DESIGN/MATERIALS AND METHODS: Thirty-six patients underwent 1, 2, or 3 treatments of their axillary or bikini area skin with a 3 milliseconds ruby laser at 10, 20, 30, or 40 J/cm(2). Biopsies were taken 3, 4(1/2), or 6 months after the last treatment and examined histologically. Nine control biopsies were taken from comparable bikini areas of untreated patients and similarly evaluated histologically. RESULTS: There was a significant increase in telogen compared to anagen follicles in treated skin, which was slightly increased by multiple compared to single treatments, but unaffected by different time intervals since the last treatment. There was also a significant increase in miniaturized compared to terminal hairs in treated compared to control skin, a finding that was further increased with higher energies used. Multiple treatments and time after treatment had a slight, but not statistically significant effect on follicle size. CONCLUSIONS: Induction of telogen in terminal follicles followed by miniaturization appears to be the main mechanism of ruby laser hair reduction.
Authors:
Sue McCoy; Anne Evans; Craig James
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Journal Article    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  30     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-12     Completed Date:  2002-09-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Affiliation:
Laser, Skin and Vein Clinic, 262 Melbourne Street, North Adelaide, South Australia, 5006. suemccoy@senet.com.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Chi-Square Distribution
Female
Hair Follicle / pathology*,  surgery*
Hair Removal / methods*
Humans
Laser Therapy / methods*
Photomicrography
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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