| Long-pulsed dye laser versus intense pulsed light for photodamaged skin: a randomized split-face trial with blinded response evaluation. | |
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MedLine Citation:
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PMID: 18563775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In a randomized controlled split-face trial to evaluate efficacy and adverse effects from rejuvenation with long-pulsed dye laser (LPDL) versus intense pulsed light (IPL). MATERIALS AND METHODS: Twenty female volunteers with Fitzpatrick skin types I-III, classes I-II rhytids, and symmetrical split-face photodamage were included in the study. Subjects received a series of three treatments at 3-week intervals with half-face LPDL (V-beam Perfecta, 595 nm, Candela Laser Corporation) and half-face IPL (Ellipse Flex, Danish Dermatologic Development); the interventions being randomly assigned to left and right sides. Primary end-points were telangiectasias, irregular pigmentation and preferred treatment. Secondary end-points were skin texture, rhytids, pain, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical on-site and photographic evaluations at 1, 3, and 6 months postoperatively. Adverse effects were evaluated by blinded clinical on-site evaluations. RESULTS: Telangiectasia improved from LPDL and IPL treatments with superior vessel clearance from LPDL treatments (postoperative side-to-side evaluations, patient self-assessments, P<or=0.031, 3, 6 months). Irregular pigmentation and skin texture improved from both treatments with no significant side-to-side differences. No reduction was seen of rhytides on LPDL- or IPL-treated sides. Treatment-related pain scores were significantly higher after IPL (medians 7-8) than LPDL (4.75-5.5) treatments (P<0.001). Adverse effects included erythema, oedema, and transient hyperpigmentation. Patients preferred LPDL- to IPL treatments (P<or=0.031). CONCLUSION: This study was based on two specific laser and IPL equipments, which found LPDL rejuvenation advantageous to IPL rejuvenation due to superior vessel clearance and less pain. |
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Authors:
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Gitte F Jørgensen; Lene Hedelund; Merete Haedersdal |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 40 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-24 Completed Date: 2008-11-18 Revised Date: 2008-12-19 |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
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Languages: eng Pagination: 293-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Double-Blind Method Face Female Humans Lasers, Dye / adverse effects, therapeutic use* Middle Aged Pain, Postoperative / etiology Patient Satisfaction Phototherapy* / adverse effects Pigmentation Disorders / etiology Skin Aging* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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