Document Detail

Long-pulsed dye laser versus intense pulsed light for photodamaged skin: a randomized split-face trial with blinded response evaluation.
MedLine Citation:
PMID:  18563775     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In a randomized controlled split-face trial to evaluate efficacy and adverse effects from rejuvenation with long-pulsed dye laser (LPDL) versus intense pulsed light (IPL). MATERIALS AND METHODS: Twenty female volunteers with Fitzpatrick skin types I-III, classes I-II rhytids, and symmetrical split-face photodamage were included in the study. Subjects received a series of three treatments at 3-week intervals with half-face LPDL (V-beam Perfecta, 595 nm, Candela Laser Corporation) and half-face IPL (Ellipse Flex, Danish Dermatologic Development); the interventions being randomly assigned to left and right sides. Primary end-points were telangiectasias, irregular pigmentation and preferred treatment. Secondary end-points were skin texture, rhytids, pain, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical on-site and photographic evaluations at 1, 3, and 6 months postoperatively. Adverse effects were evaluated by blinded clinical on-site evaluations. RESULTS: Telangiectasia improved from LPDL and IPL treatments with superior vessel clearance from LPDL treatments (postoperative side-to-side evaluations, patient self-assessments, P<or=0.031, 3, 6 months). Irregular pigmentation and skin texture improved from both treatments with no significant side-to-side differences. No reduction was seen of rhytides on LPDL- or IPL-treated sides. Treatment-related pain scores were significantly higher after IPL (medians 7-8) than LPDL (4.75-5.5) treatments (P<0.001). Adverse effects included erythema, oedema, and transient hyperpigmentation. Patients preferred LPDL- to IPL treatments (P<or=0.031). CONCLUSION: This study was based on two specific laser and IPL equipments, which found LPDL rejuvenation advantageous to IPL rejuvenation due to superior vessel clearance and less pain.
Gitte F Jørgensen; Lene Hedelund; Merete Haedersdal
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  40     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-11-18     Revised Date:  2008-12-19    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  IM    
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
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MeSH Terms
Double-Blind Method
Lasers, Dye / adverse effects,  therapeutic use*
Middle Aged
Pain, Postoperative / etiology
Patient Satisfaction
Phototherapy* / adverse effects
Pigmentation Disorders / etiology
Skin Aging*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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