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Long noncoding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival.
MedLine Citation:
PMID:  23281836     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Identification of new nasopharyngeal carcinoma (NPC) biomarkers is of great clinical value for the diagnosis and treatment of NPC. HOTAIR, a cancer-related long noncoding RNA, was tested and its prognostic value for NPC was evaluated. Determined by In situ hybridization (ISH), 91 of 160 (56.87%) paraffin-embedded NPC biopsies showed high expression levels of HOTAIR (Staing Index, SI score ≥ 6). HOTAIR was up-regulated in tumors with a larger tumor (p = 0.021), more advanced clinical staging (P = 0.012) and increased lymph node tumor burden (P = 0.005). Quantified by real-time PCR, HOTAIR expression levels in fresh tissue and paraffin-embedded samples were 5.2˜48.4-fold higher compared with non-cancer tissue samples. Moreover, HOTAIR expression levels increased with clinical stage progression, which was consistent with ISH findings in the paraffin-embedded tissue. Most importantly, NPC patients with higher HOTAIR levels had poor prognosis for overall survival by univariate and multivariate analysis. In addition, HOTAIR mediated the migration, invasion and proliferation of NPC cells in vitro. HOTAIR is a potential biomarker for the prognosis of NPC, and dysregulation of HOTAIR may play an important role in NPC progression.
Authors:
Yan Nie; Xiang Liu; Shaohua Qu; Erwei Song; Hua Zou; Chang Gong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Japanese Cancer Association.
Affiliation:
Breast Tumor Center; Key Laboratory of Malignant Tumor Gene Regulation, Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
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