Document Detail

Long-lasting sensitization of reward-directed behavior by amphetamine.
MedLine Citation:
PMID:  19428619     Owner:  NLM     Status:  MEDLINE    
Exposure to psychostimulant drugs of abuse such as amphetamine can result in long-lasting "sensitization" of reward-directed behavior, such that subjects display enhancements in behavior directed by and toward rewards and reward-predictive cues (i.e. "incentive sensitization"). The purpose of these experiments was to determine the degree to which such sensitization resulting from chronic amphetamine exposure influences both appetitive and consummatory food-motivated behavior. Adult male Long-Evans rats received daily i.p. injections of D-amphetamine (2.0 mg/kg) or saline vehicle for five consecutive days. This amphetamine exposure regimen produced lasting sensitization to the acute locomotor stimulant effect of the drug. One month after drug exposure rats were tested for instrumental responding (lever pressing) for food reward under various response schedules. Two months after drug exposure, rats were tested for food consumption in a discriminative Pavlovian context-potentiated eating task, involving pairings of one context with food and another context with no food. Amphetamine exposed rats showed significantly greater instrumental responding for food reward than saline controls, particularly under conditions of high response ratios. In the potentiated eating task, testing under conditions of food satiation revealed that amphetamine exposed rats ate significantly more than saline controls in the food-paired context. These experiments demonstrate that amphetamine exposure can cause enduring increases in both appetitive and consummatory aspects of natural reward-directed behavior. Such long-lasting incentive sensitization could account in part for the propensity for relapse in drug addiction, as well as for reported enhancements in non-drug reward-related behavior.
Ian A Mendez; Matthew T Williams; Atasi Bhavsar; Annie P Lu; Jennifer L Bizon; Barry Setlow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-02-06
Journal Detail:
Title:  Behavioural brain research     Volume:  201     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-08-13     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Central Nervous System Stimulants / administration & dosage*
Conditioning, Classical / drug effects
Dextroamphetamine / administration & dosage*
Feeding Behavior / drug effects*
Motor Activity / drug effects
Rats, Long-Evans
Grant Support
T32 MH065728/MH/NIMH NIH HHS; T32 MH065728-07/MH/NIMH NIH HHS; T32 MH65728/MH/NIMH NIH HHS
Reg. No./Substance:
0/Central Nervous System Stimulants; TZ47U051FI/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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