Document Detail

Long-lasting neural and behavioral effects of iron deficiency in infancy.
MedLine Citation:
PMID:  16770951     Owner:  NLM     Status:  MEDLINE    
Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.
Betsy Lozoff; John Beard; James Connor; Felt Barbara; Michael Georgieff; Timothy Schallert
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  64     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-06-29     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S34-43; discussion S72-91     Citation Subset:  IM    
Center for Human Growth and Development and the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor 48109, USA.
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MeSH Terms
Anemia, Iron-Deficiency / complications*
Brain / metabolism
Disease Models, Animal
Follow-Up Studies
Growth and Development
Infant, Newborn
Iron / deficiency*
Mental Disorders / epidemiology*,  etiology
Myelin Sheath / physiology
Nervous System Diseases / epidemiology*,  etiology
Neurotransmitter Agents / physiology
Grant Support
P01 HD039386-01A1/HD/NICHD NIH HHS; P01 HD039386-02/HD/NICHD NIH HHS; P01 HD039386-03/HD/NICHD NIH HHS; P01 HD039386-04/HD/NICHD NIH HHS; P01 HD039386-05/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS
Reg. No./Substance:
0/Neurotransmitter Agents; 7439-89-6/Iron

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