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Long-lasting enhancement of GABA(A) receptor expression in newborn dentate granule cells after early-life febrile seizures.
MedLine Citation:
PMID:  22378685     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Febrile seizures (FS) are the most common type of seizures in childhood and are suggested to play a role in the development of temporal lobe epilepsy (TLE). Animal studies demonstrated that experimental FS induce a long-lasting change in hippocampal excitability, resulting in enhanced seizure susceptibility. Hippocampal neurogenesis and altered ion channel expression have both been proposed as mechanisms underlying this decreased seizure threshold. The present study aimed to analyze whether dentate gyrus (DG) cells that were born after FS and matured for 8 weeks, display an altered repertoire of ligand-gated ion channels. To this end we applied an established model, in which FS are elicited in 10-day old rat pups by hyperthermia (HT). Normothermia (NT) littermates serve as controls. From postnatal day 11 (P11) to P16, rats were injected with bromodeoxyuridine (BrdU) to label dividing cells immediately following FS. At P66, we evaluated BrdU-labeled DG cells for co-expression with γ-aminobutyric acid type A receptors (GABA(A) Rs) and N-methyl-D-aspartate receptors (NMDARs). In control animals, 40% of BrdU-labeled cells co-expressed GABA(A) R β2/3 whereas in rats that had experienced FS 60% of BrdU-labeled cells also expressed GABA(A) R β2/3. The number of BrdU-NMDAR NR2A/B co-expressing cells was in both groups about 80% of BrdU-labeled cells. The results demonstrate that developmental seizures cause a long-term increase in GABA(A) R β2/3 expression in newborn DG cells. This may affect hippocampal physiology. © 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012.
Authors:
Ann Swijsen; Bert Brône; Jean-Michel Rigo; Govert Hoogland
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-29
Journal Detail:
Title:  Developmental neurobiology     Volume:  -     ISSN:  1932-846X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300215     Medline TA:  Dev Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
BIOMED Research Institute, Hasselt University and transnational University Limburg, Agoralaan Bld C, 3590 Diepenbeek, Belgium.
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