Document Detail


Long-lasting cardiovascular depression induced by acupuncture-like stimulation of the sciatic nerve in unanaesthetized spontaneously hypertensive rats.
MedLine Citation:
PMID:  7201339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of a prolonged low frequency electrical stimulation of the somatic afferents on cardiovascular and sympathetic nerve activities was investigated in unanaesthetized spontaneously hypertensive rats (SHRs) and Wistar-Kyoto normotensive rats (WKRs). In SHR, an elevation of blood pressure, heart rate and splanchnic nerve outflow was elicited during a 30-min period of sciatic nerve stimulation. Following the cessation of the stimulation, depressor response and bradycardia slowly developed and lasted up to 12 h. Activation of the group III or A-delta afferent fibers was essential for this post-stimulatory response. The progressive depressor response and a parallelled reduction of the splanchnic nerve activity, reached their maxima at about 1 h after the termination of the sciatic stimulation. The magnitude of the post-stimulatory depressor response was correlated with the prestimulatory control blood pressure level. There were also behavioural changes accompanying the depressor response. The cardiovascular and the behavioural depression were immediately reversed by naloxone (10-15 mg/kg, i.v.). The post-stimulatory depressor response was still present after bilateral sino-aortic denervation, but was absent in animals anaesthetized with chloralose and urethane. Emotional stress produced by air-blowing on the animal resulted in pressor response and tachycardia during the period of the stressful stimulation, but there was no depressor response following the termination of air-blowing. These findings indicate a sympathetic and cardiovascular depression induced by a prolonged stimulation of the somatic group III or A-delta afferent fibers; its long duration and naloxone reversibility suggest the involvement of endorphins in the mechanism of this response. The physiological significance of the effects of the prolonged somatic afferent stimulation and its possible relations with acupuncture are discussed.
Authors:
T Yao; S Andersson; P Thorén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  240     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acupuncture Therapy
Animals
Behavior, Animal / physiology
Cardiovascular Diseases / drug therapy,  etiology*
Chronic Disease
Consciousness
Electric Stimulation / adverse effects*
Humans
Hypertension / physiopathology*
Male
Naloxone / therapeutic use
Rats
Rats, Mutant Strains
Sciatic Nerve / physiopathology*
Splanchnic Nerves / physiopathology
Stress, Psychological / physiopathology
Chemical
Reg. No./Substance:
465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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