Document Detail

Long-lasting adverse effects of prenatal hypoxia on developing autonomic nervous system and cardiovascular parameters in rats.
MedLine Citation:
PMID:  11889586     Owner:  NLM     Status:  MEDLINE    
To determine whether prenatal hypoxia increases the risk of developing cardiovascular disorders as an adult and, if so, the identity of the cell mechanisms involved in such dysfunction, we evaluated the sympathoadrenal system and central areas related to cardiovascular events during development and the cardiovascular parameters in adults. Pregnant rats were exposed to hypoxia (10% oxygen) from embryonic day (E) 5 to E20 and the offspring studied at 1, 3, 9 and 12 weeks of age for neurochemistry and at 12 weeks of age for cardiovascular analysis. In the 1-, 3- and 9-week-old offspring, the levels and utilization of catecholamines were reduced in sympathetic ganglia, in target organs, in adrenals and in the rostral part of the A2 cell group in the nucleus tractus solitarius, but were increased in the locus coeruleus. In the 12-week-old adult offspring, the lowered autonomic nervous activity was restricted to cardiac-related structures, i.e. the stellate ganglion, heart and adrenals. In adult rats, prenatal hypoxia did not affect the cardiac parameters under resting conditions but increased blood pressure and the variability of blood pressure and heart rate under stress conditions. The altered metabolic activity of the sympathoadrenal system and related central areas during development and at adulthood for most structures might be part of the potential mechanisms contributing to cardiovascular disorders in adults.
Julie Peyronnet; Yvette Dalmaz; Marcus Ehrström; Julie Mamet; Jean-Christophe Roux; Jean-Marc Pequignot; H Peter Thorén; Hugo Lagercrantz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-01-24
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  443     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-12     Completed Date:  2002-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  858-65     Citation Subset:  IM    
Department of Woman and Child Health, Karolinska Institute, 171 76 Stockholm, Sweden.
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MeSH Terms
Adrenal Glands / metabolism
Anoxia / physiopathology*
Blood Pressure
Cardiovascular System / embryology*,  metabolism
Heart Rate
Locus Coeruleus / embryology,  metabolism
Myocardium / metabolism
Norepinephrine / metabolism
Organ Size
Oxygen / pharmacology
Prenatal Exposure Delayed Effects
Rats, Sprague-Dawley
Stellate Ganglion / embryology*,  metabolism
Stress, Physiological / physiopathology
Reg. No./Substance:
51-41-2/Norepinephrine; 7782-44-7/Oxygen

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