Document Detail

Long-duration response to levodopa influences the pharmacodynamics of short-duration response in Parkinson's disease.
MedLine Citation:
PMID:  9266736     Owner:  NLM     Status:  MEDLINE    
The long-duration response (LDR) to chronic levodopa treatment may mask the short-duration response (SDR) to a single dose of the drug in Parkinson's disease (PD). As a result, the measurement of SDR may be inaccurate for establishing levodopa dosing regimen in individual patients. To evaluate the possible contamination of SDR by LDR, we investigated in 16 patients with PD the characteristics of SDR to a single dose of levodopa administered after a prolonged washout from chronic therapy and after a 15-day treatment period with levodopa. Levodopa treatment produced a sustained LDR, and the SDR, measured on the 15th day of treatment, had lower magnitude and shorter duration than the response recorded after washout. Moreover, after treatment, SDR did not vary between patients with mild and severe PD, whereas, after washout, severely affected patients had larger but shorter SDR than mildly affected patients. The evaluation of SDR without the interference of LDR is critical in defining the characteristics of the therapeutic response to levodopa.
M Zappia; R Colao; R Montesanti; M Rizzo; U Aguglia; A Gambardella; R L Oliveri; A Quattrone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  42     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-05     Completed Date:  1997-09-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-8     Citation Subset:  IM    
Institute of Neurology, Faculty of Medicine, University of Reggio Calabria, Catanzaro, Italy.
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MeSH Terms
Administration, Oral
Levodopa / pharmacokinetics*,  pharmacology,  therapeutic use*
Middle Aged
Motor Activity / drug effects
Movement / drug effects
Parkinson Disease / drug therapy*,  physiopathology*
Reproducibility of Results
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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