Document Detail

Long-chain polyunsaturated fatty acid content in Dutch preterm breast milk; differences in the concentrations of docosahexaenoic acid and arachidonic acid due to length of gestation.
MedLine Citation:
PMID:  8654314     Owner:  NLM     Status:  MEDLINE    
Recognizing the important role of long-chain polyunsaturated fatty acids (LCP) particularly in preterm infant nutrition, we studied the fatty acid composition of breast milk from 65 mothers of very preterm ( < 31 weeks of gestation) and preterm ( > or = 31 and < 36 weeks of gestation) infants. Fatty acids were determined as fatty acid methyl esters by capillary gas chromatography. In accordance with other studies, the increase of capric acid, lauric acid and myristic acid during lactation is influenced by prematurity. Unsaturated fatty acids had the inclination to decrease. Our interest was mainly focused on docosahexaenoic acid (DHA) and arachidonic acid (AA). Accelerated brain growth during the last trimester of gestation requires an extra need for these LCPs. In our study, preterm milk after a gestation period of at least 32 weeks contained the highest amounts of DHA and AA. The Western maternal diet is considered to be low in omega 3 fatty acids, that is why the concentration of DHA in our preterm milk can be regarded as a low amount. As it is the milk of their mothers, and because the amounts are higher than normally found in Western full term breast milk, the contribution of DHA to preterm milk fat (0.34%) might be considered, for the time being, as a safe natural guideline for formulas for preterm infants.
R J Beijers; A Schaafsma
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Early human development     Volume:  44     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-07-30     Completed Date:  1996-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  215-23     Citation Subset:  IM    
Neonatal Centre, Saint Joseph Hospital, Veldhoven, The Netherlands.
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MeSH Terms
Arachidonic Acid / analysis*
Colostrum / chemistry
Docosahexaenoic Acids / analysis*
Fatty Acids, Unsaturated / analysis*
Gestational Age*
Infant, Newborn
Infant, Premature*
Milk, Human / chemistry*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

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