Document Detail

Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial.
MedLine Citation:
PMID:  12727766     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether supplementation of infant formula milk with long chain polyunsaturated fatty acids (LCPUFAs) influences blood pressure in later childhood.
DESIGN: Follow up of a multicentre, randomised controlled trial.
SETTING: Four study centres in Europe.
PARTICIPANTS: 147 formula fed children, with a reference group of 88 breastfed children.
INTERVENTION: In the original trial newborn infants were randomised to be fed with a formula supplemented with LCPUFAs (n=111) or a formula without LCPUFAs but otherwise nutritionally similar (n=126). In the present follow up study the blood pressure of the children at age 6 years was measured.
MAIN OUTCOME MEASURES: Systolic, diastolic, and mean blood pressure.
RESULTS: 71 children in the LCPUFA supplementation group (64% of the original group) and 76 children in the non-supplementation group (60%) were enrolled into the follow up study. The LCPUFA group had significantly lower mean blood pressure (mean difference -3.0 mm Hg (95% confidence interval -5.4 mm Hg to -0.5 mm Hg)) and diastolic blood pressure (mean difference -3.6 mm Hg (-6.5 mm Hg to -0.6 mm Hg)) than the non-supplementation group. The diastolic pressure of the breastfed children (n=88 (63%)) was significantly lower than that of the non-supplemented formula group but did not differ from the LCPUFA formula group.
CONCLUSIONS: Dietary supplementation with LCPUFAs during infancy is associated with lower blood pressure in later childhood. Blood pressure tends to track from childhood into adult life, so early exposure to dietary LCPUFAs may reduce cardiovascular risk in adulthood.
J S Forsyth; P Willatts; C Agostoni; J Bissenden; P Casaer; G Boehm
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  326     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-02     Completed Date:  2003-05-09     Revised Date:  2012-03-06    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  953     Citation Subset:  AIM; IM    
Tayside Institute of Child Health, University of Dundee, Dundee DD1 9SY.
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MeSH Terms
Blood Pressure / physiology*
Bottle Feeding
Dietary Supplements*
Fatty Acids, Unsaturated / administration & dosage*
Follow-Up Studies
Infant Food*
Infant, Newborn
Reg. No./Substance:
0/Fatty Acids, Unsaturated
Comment In:
BMJ. 2003 Sep 20;327(7416):683   [PMID:  14500454 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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