| Long chain n-3 PUFA-rich meal reduced postprandial measures of arterial stiffness. | |
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MedLine Citation:
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PMID: 20199827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: The consumption of long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) is known to be cardio-protective. Data on the influence of LC n-3 PUFA on arterial stiffness in the postprandial state is limited. The aim of this study was to investigate the acute effects of a LC n-3 PUFA-rich meal on measures of arterial stiffness. METHODS: Twenty-five healthy subjects (12 men, 13 women) received a control and a LC n-3 PUFA-rich meal on two occasions in a random order. Arterial stiffness was measured at baseline, 30, 60, 90, 120, 180 and 240 min after meal consumption by pulse wave analysis and digital volume pulse to derive an augmentation index and a stiffness index respectively. Blood samples were taken for measurement of lipids, glucose and insulin. RESULTS: Consumption of the LC n-3 PUFA-rich meal had an attenuating effect on augmentation index (P=0.02) and stiffness index (P=0.03) compared with the control meal. A significant treatment effect (P=0.036) was seen for plasma non-esterified fatty acids concentrations. CONCLUSIONS: These data indicate that acute LC n-3 PUFA-rich meal consumption can improve postprandial arterial stiffness. This has important implications for the beneficial properties of LC n-3 PUFA and cardiovascular risk reduction. |
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Authors:
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Mary F-F Chong; Stacey Lockyer; Caroline J Saunders; Julie A Lovegrove |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-03-02 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 29 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 678-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, University of Reading, Reading, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteries / pathology* Blood Glucose / analysis Cross-Over Studies Fatty Acids, Nonesterified / blood Fatty Acids, Omega-3 / administration & dosage*, metabolism* Female Humans Insulin / blood Lipids / blood Male Middle Aged Postprandial Period* Single-Blind Method Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Lipids; 11061-68-0/Insulin |
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