| Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the beta2-adrenoceptor activity. | |
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MedLine Citation:
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PMID: 15324892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the beta-phenethyl-amino-substituent has been extended beyond the methyl ether residue present in the parent compound are described. Evaluation of these analogues as beta(2)-adrenoceptor agonists was used to provide an insight into the factors controlling the magnitude and duration of receptor activation. |
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Authors:
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Vahid Alikhani; David Beer; David Bentley; Ian Bruce; Bernard M Cuenoud; Robin A Fairhurst; Peter Gedeck; Sandra Haberthuer; Claire Hayden; Diana Janus; Lynne Jordan; Christine Lewis; Kirsty Smithies; Elke Wissler |
Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 14 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2005-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4705-10 Citation Subset: IM |
Affiliation:
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Novartis Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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chemical synthesis,
chemistry*,
pharmacology Albuterol / analogs & derivatives*, chemistry Animals Ethanolamines / chemical synthesis, chemistry*, pharmacology Guinea Pigs Humans Muscle Contraction / drug effects Muscle, Smooth / drug effects, physiology Receptors, Adrenergic, beta-2 / agonists* Stereoisomerism Structure-Activity Relationship Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Ethanolamines; 0/Receptors, Adrenergic, beta-2; 18559-94-9/Albuterol; 73573-87-2/formoterol; 89365-50-4/salmeterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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