Document Detail


Long-acting somatostatin analogue therapy in obscure-overt gastrointestinal bleeding in noncirrhotic portal hypertension: a case report and literature review.
MedLine Citation:
PMID:  19491695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a case of obscure gastrointestinal bleeding in a male with noncirrhotic portal hypertension who required multiple admissions and repeated blood transfusions over a 5-month period. Upper and lower gastrointestinal endoscopy failed to establish a cause for bleeding which was eventually ascribed to universal portal hypertensive stigmata in stomach, small bowel and colon, which were not amenable to endoscopic therapy. On account of extensive venous thrombosis, neither surgical shunting nor interventional radiology was an option. Initial management with prothrombotic agents failed. Our patient was successfully stabilized on long-acting somatostatin (SMS) analogue therapy using lanreotide, resulting in avoidance of further admissions and blood transfusion and restoration of his independence and quality of life. The use of short-acting SMS analogues is recognised in acute variceal haemorrhage secondary to portal hypertension in cirrhosis, and long-acting SMS analogue therapy has been described in obscure gastrointestinal bleeding though secondary to angiodysplasia. However, the potential role of long-term SMS analogues in noncirrhotic portal hypertensive bleeding of this type has not been reported earlier. This case supports its use in this scenario in the absence of surgical options and when only palliative approaches are available.
Authors:
John M Hutchinson; Jason S R Jennings; Rebecca L Jones
Related Documents :
10992725 - Organo-axial volvulus of the stomach with diaphragmatic eventration.
17450495 - Primary gastric actinomycosis: a case report.
620385 - The intrauterine contraceptive device.
10535465 - Helicobacter pylori in africa: observations on an 'enigma within an enigma'.
10741525 - Synovial chondromatosis of the subcoracoid bursa.
24891835 - Why is the lawn buzzing?
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  22     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  754-8     Citation Subset:  IM    
Affiliation:
Department of Molecular Gastroenterology, Clinical Sciences Building, St. James's University Hospital, Leeds LS9 7TF, UK. johnmhutchinson@btinternet.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Esophageal and Gastric Varices / drug therapy,  etiology
Gastrointestinal Hemorrhage / diagnosis,  drug therapy*,  etiology
Humans
Hypertension, Portal / complications,  drug therapy*
Male
Middle Aged
Peptides, Cyclic / therapeutic use*
Quality of Life
Somatostatin / analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Peptides, Cyclic; 118992-92-0/lanreotide; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Injuries to cargo area passengers of heavy goods vehicles.
Next Document:  Patient-reported outcomes in patients with endocrine tumors of the ileum.