Document Detail


Long-acting nitrates: relative utility of nitroglycerin patches.
MedLine Citation:
PMID:  6430079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cutaneous nitroglycerin patches offer an attractive, convenient approach to antianginal prophylaxis with nitroglycerin. Blood level data have suggested that nitroglycerin patches could have antianginal effects for 24 hours or more. However, direct documentation of antianginal efficacy is fragmentary at present. Existing studies using provocative exercise testing, with one exception, do not demonstrate antianginal effects of nitroglycerin patches at 24 hours, using either low or maximal tolerated doses in each subject. Furthermore, in contrast to other long-acting nitrates evaluated in similar fashion, the peak effects of nitroglycerin patches may not be as potent as those of sublingual nitroglycerin. Thus, at present, clinicians should not assume that nitroglycerin patches can provide 24-hour prophylaxis. Further, in patients on a patch regimen with continuing symptoms, consideration should be given to a trial of alternative or additional long-acting nitrates of other types.
Authors:
N Reichek
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  76     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-07     Completed Date:  1984-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Angina Pectoris / prevention & control*
Clinical Trials as Topic
Double-Blind Method
Exercise Test
Humans
Nitroglycerin / administration & dosage*
Grant Support
ID/Acronym/Agency:
RR0040/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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