Document Detail


Long-acting injectable antipsychotics in early psychosis: a literature review.
MedLine Citation:
PMID:  23342964     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: There are sound reasons for considering the use of long-acting injectable antipsychotics early in the course of schizophrenia. We reviewed available literature on the subject. METHOD: We conducted an electronic database search and critically reviewed all studies in which a long-acting injectable antipsychotic was evaluated in early psychosis patients. RESULTS: There is a need for well-designed studies as most of those reported were open-label and non-comparative, and samples were frequently small. CONCLUSIONS: The available evidence does suggest that long-acting injectable antipsychotics can be used safely and effectively in early stages of the illness, and that they may be associated with better outcomes than with oral medications. However, this is largely supported by evidence from naturalistic cohort studies and a small number of controlled trials of risperidone long-acting injection. Evidence for olanzapine and paliperidone long-acting injectables in particular is limited.
Authors:
Robin Emsley; Bonginkosi Chiliza; Laila Asmal; Mpogisheng Mashile; Paolo Fusar-Poli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Early intervention in psychiatry     Volume:  -     ISSN:  1751-7893     ISO Abbreviation:  Early Interv Psychiatry     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101320027     Medline TA:  Early Interv Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Psychiatry, Faculty of Heath Sciences, University of Stellenbosch, Cape Town, South Africa.
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