Document Detail


Long-term treatment with shengmai san-derived herbal supplement (Wei Kang Su) enhances antioxidant response in various tissues of rats with protection against carbon tetrachloride hepatotoxicity.
MedLine Citation:
PMID:  20192847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wei Kang Su (WKS) is a commercial herbal product based on a Chinese herbal formula, Shengmai San. Here, we investigated the effects of long-term treatment with WKS on mitochondrial antioxidant status and functional ability, as well as heat shock protein (Hsp) 25/70 production, in various tissues of rats. WKS treatment enhanced mitochondrial antioxidant status and ATP generation capacity, as well as Hsp 25/70 production in various rat tissues. WKS treatment suppressed plasma reactive oxygen metabolite levels and protected against carbon tetrachloride hepatotoxicity in rats. Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress.
Authors:
Pou Kuan Leong; Na Chen; Po Yee Chiu; Hoi Yan Leung; Chung Wah Ma; Qing Tao Tang; Kam Ming Ko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  13     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-38     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Hong Kong University of Science & Technology, Hong Kong Special Administrative Region, China.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / biosynthesis
Angiosperms*
Animals
Antioxidants / metabolism,  pharmacology,  therapeutic use*
Carbon Tetrachloride Poisoning / drug therapy*,  metabolism
Drug-Induced Liver Injury / metabolism,  prevention & control*
Drugs, Chinese Herbal / pharmacology,  therapeutic use*
Female
HSP20 Heat-Shock Proteins / biosynthesis
HSP70 Heat-Shock Proteins / biosynthesis
Mitochondria / drug effects,  metabolism
Ophiopogon
Oxidative Stress / drug effects*
Panax
Phytotherapy*
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species / blood
Schisandra
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Drugs, Chinese Herbal; 0/HSP20 Heat-Shock Proteins; 0/HSP70 Heat-Shock Proteins; 0/Reactive Oxygen Species; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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