Document Detail

Long-term reprogramming of cardiovascular function in infants of active smokers.
MedLine Citation:
PMID:  20100999     Owner:  NLM     Status:  MEDLINE    
Newborn infants of smokers show symptoms of cardiovascular stress hyperreactivity. Persistent hyperreactivity could increase the risk of short- and/or long-term complications, such as hypertension. Here we determined whether incipient dysfunction in a smoker's infant persists or worsens with age, by comparing cardiovascular reflex function of control and tobacco-exposed infants longitudinally from birth to 1 year. We compared infants born at term to nonsmoking couples (controls; n=19) and mothers who smoked moderately (average consumption=15 cigarettes per day; n=17). All were tested at 1 to 3 weeks, 3 months, and 1 year during sleep. We recorded blood pressure and heart rate noninvasively during passive repositioning (60 degrees head-up tilt). Tilting control infants raised blood pressure slightly above baseline at 1 week (+2%) and much more at 1 year (+10%). This trend was reversed in the tobacco-exposed cohort (+10% at 1 week but only +4% at 1 year). At 3 months and 1 year, the heart rate response of tobacco-exposed infants to tilt was also abnormal (highly exaggerated). Our study reveals that maternal smoking leads to long-lasting "reprogramming" of infant blood pressure control mechanisms. The underlying dysfunction in a smoker's infant could plausibly be a precursor or early marker of long-term susceptibility to complications, such as raised blood pressure.
Gary Cohen; Heather Jeffery; Hugo Lagercrantz; Miriam Katz-Salamon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-25
Journal Detail:
Title:  Hypertension     Volume:  55     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-19     Completed Date:  2010-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-8     Citation Subset:  IM    
Department of Women and Child Health, Neonatal Unit, Karolinska Institute, Elevhemmet H1-02, S-171 76 Stockholm, Sweden.
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MeSH Terms
Blood Pressure / physiology
Follow-Up Studies
Heart Rate / physiology
Hypertension / epidemiology*,  physiopathology*
Infant, Newborn
Longitudinal Studies
Posture / physiology
Prenatal Exposure Delayed Effects / epidemiology*,  physiopathology*
Risk Factors
Smoking / epidemiology*,  physiopathology*
Tobacco Smoke Pollution / statistics & numerical data
Vagus Nerve / physiology
Vasoconstriction / physiology
Veins / physiology
Reg. No./Substance:
0/Tobacco Smoke Pollution
Comment In:
Hypertension. 2010 Mar;55(3):614-6   [PMID:  20100994 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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