| Long-term reprogramming of cardiovascular function in infants of active smokers. | |
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MedLine Citation:
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PMID: 20100999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Newborn infants of smokers show symptoms of cardiovascular stress hyperreactivity. Persistent hyperreactivity could increase the risk of short- and/or long-term complications, such as hypertension. Here we determined whether incipient dysfunction in a smoker's infant persists or worsens with age, by comparing cardiovascular reflex function of control and tobacco-exposed infants longitudinally from birth to 1 year. We compared infants born at term to nonsmoking couples (controls; n=19) and mothers who smoked moderately (average consumption=15 cigarettes per day; n=17). All were tested at 1 to 3 weeks, 3 months, and 1 year during sleep. We recorded blood pressure and heart rate noninvasively during passive repositioning (60 degrees head-up tilt). Tilting control infants raised blood pressure slightly above baseline at 1 week (+2%) and much more at 1 year (+10%). This trend was reversed in the tobacco-exposed cohort (+10% at 1 week but only +4% at 1 year). At 3 months and 1 year, the heart rate response of tobacco-exposed infants to tilt was also abnormal (highly exaggerated). Our study reveals that maternal smoking leads to long-lasting "reprogramming" of infant blood pressure control mechanisms. The underlying dysfunction in a smoker's infant could plausibly be a precursor or early marker of long-term susceptibility to complications, such as raised blood pressure. |
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Authors:
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Gary Cohen; Heather Jeffery; Hugo Lagercrantz; Miriam Katz-Salamon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-25 |
Journal Detail:
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Title: Hypertension Volume: 55 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-03-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 722-8 Citation Subset: IM |
Affiliation:
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Department of Women and Child Health, Neonatal Unit, Karolinska Institute, Elevhemmet H1-02, S-171 76 Stockholm, Sweden. Gary.Cohen@ki.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology Female Follow-Up Studies Heart Rate / physiology Humans Hypertension / epidemiology*, physiopathology* Infant, Newborn Longitudinal Studies Male Parents Posture / physiology Pregnancy Prenatal Exposure Delayed Effects / epidemiology*, physiopathology* Risk Factors Smoking / epidemiology*, physiopathology* Tobacco Smoke Pollution / statistics & numerical data Vagus Nerve / physiology Vasoconstriction / physiology Veins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Tobacco Smoke Pollution |
| Comments/Corrections | |
Comment In:
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Hypertension. 2010 Mar;55(3):614-6
[PMID:
20100994
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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